Centre de Recherche en Nutrition Humaine d'Auvergne

Microflore intestinale,
nutrition préventive et santé

Effets des fruits et légumes sur la santé
Métabolisme protéino-énergétique
et vieillissement
1998 1999 2000 2001 2002
1998 1999 2000 2001 2002
1998 1999 2000 2001 2002
Présentation

Les publications des chercheurs du CRNH

Actualités

Microflore intestinale, nutrition préventive et santé

1998
Bonnet, R., Souweine, B., Gauthier, G., Rich, C., Livrelli, V., Sirot, J., Joly, B. and Forestier C. (1998) Non-O157:H7 Stx2-encoding Escherichia coli strains associated with sporadic cases of hemolytic-uremic syndrome in adults. J. Clin. Microbiol. 36, 1777-1780.

Darfeuille-Michaud, A., Neut, C., Barnich, N., Lederman, E., Di Martino, P., Desreumaux, P., Gambiez, L., Joly, B. and Colombel, J.F. (1998) Presence of adherent Escherichia coli strains in ileal mucosa of patients with Crohn's disease. Gastroenterology. 115, 1405-1413.

Favre-Bonte, S., Forestier, C. and Joly, B. (1998) Inhibitory effect of roxithromycin on adhesion of Klebsiella pneumoniae strains 3051, CF504 and LM21. J. Antimicrob. Chemother. 41 Sup. B, 51-55.

Leclerc, M., Bensaid-elfoul, L. and Bernalier, A. (1998) Effect of yeast extract on growth and metabolism of H2-utilizing acetogenic bacteria from the human colon. Curr. Microbiol. 37, 166-171.

Thèmes de Recherche
Laboratoires du CRNH
Publications
Thèses & Post-docs
Animations scientifiques
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1999
Boudeau, J., Glasser, AL., Masseret, E., Joly, B. and Darfeuille-Michaud, A. (1999) Invasive ability of an Escherichia coli strain isolated from the ileal mucosa of a patient with Crohn's disease. Infect. Immun. 67, 4499-4509.

Bulois, P., Desreumaux, P., Neut, C., Darfeuille-Michaud, A., Cortot, A. and Colombel, JF. (1999) Infectious agents and Crohn's disease. Clin. Microbiol. Infect. 5, 601-604.

Dapoigny, M. Functional intestinal disorders (1999) Diagnosis and treatment. Rev Prat. 15, 49(14),1559-64.

Favre-Bonte, S., Joly, B. and Forestier, C. (1999) Consequences of reduction of Klebsiella pneumoniae capsule expression on interactions of this bacterium with epithelial cells. Infect. Immun. 67, 554-561.

Favre-Bonte, S., Rask licht, T., Forestier, C., and Krogfelt, K.A.. (1999) Klebsiella pneumoniae capsule expression is necessary for colonization of large intestines of streptomycin-treated mice. Infect. Immun. 67, 6152-6156.

Harel, J. and Martin, C. (1999) Virulence gene regulation in pathogenic Escherichia coli. Vet. Research 30,131-155.
Havenaar, R., Marol-Bonin, S., Van Dokkum, W., Petitet, S. and Shaafsma, G.(1999) Inulin: Fermentation and microbial ecology in the intestinal tract. Food Review International 15(1): 109-120.

Minekus, M., Smeets-Peeters, M., Bernalier, A., Marol, S., Havenaar, R., Marteau, P., Alric, M., Fonty, G. and Huis in't Veld, J.H.J. (1999) A computer-controlled model of the large intestine with peristaltic mixing, absorption of fermentation products and a high-density microflora. Appl. Microbiol. Biotechnol. 53 (1), 108-114.

Stockbrugger, R., Coremans, G., Creed, F., Dapoigny, M., Muller-Lissner, S.A., Pace, F., Smout, A. and Whorwell, P.J. (1999) Psychosocial background and intervention in the irritable bowel syndrome. Digestion 60(2),175-86

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2000
Azpiroz, F., Dapoigny, M., Pace, F., Muller-Lissner, S., Coremans, G., Whorwell, P., Stockbrugger, R.W. and Smout A. (2000) Non gastrointestinal disorders in the irritable bowel syndrome. Digestion 62(1), 66-72.

Bertin, Y.,Girardeau, J.P., DarfeuilleMichaud, A. and Martin, C. (2000) Epidemiological study of pap genes among diarrheagenic or septicemic Escherichia coli strains producing CS31A and F17 adhesins and characterization of Pap(31A) fimbriae. J. Clin. Microbiol. 38,1502-1509.

Boukhors, K., Pradel, N., Girardeau, J.P., Bertin, Y., Livrelli, V., Contrepois, M. and Martin, C. (2000) The rumen as a reservoir for pathogenic VTEC strains. Reprod. Nutr. Develop. 40 :215-216.

Daigle, F., Forget, C., Martin, C., Drolet, M., Tessier, M.C., Dezfulian, H. and Harel, J. (2000) Effects of global regulatory proteins and environmental conditions on fimbrial gene expression of F165(1) and F165(2) produced by Escherichia coli causing septicaemia in pigs. Research Microbiol. 151, 563-574.

Pradel, N., Livrelli, V., De Champs, C., Pacloux, J-B., Reynaud, A., Scheutz, F., Sirot, J., Joly, B. and Forestier, C. (2000) Prevalence and characterization of Shiga toxin-producing Escherichia coli isolated from cattle, food, and children during a one-year prospective study in France. J. Clin. Microbiol. 38, 1023-1031.

Smout, A., Azpiroz, F., Coremans, G., Dapoigny, M., Collins, S., Muller-Lissner, S., Pace, F., Stockbrugger, R., Vatn, M. and Whorwell, P. (2000) Potential pitfalls in the differential diagnosis of irritable bowel syndrome. Digestion 61(4), 247-56.

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2001
Boudeau J., Barnich N., Darfeuille-Michaud A.Type 1 pili-mediated adherence of Escherichia coli strain LF82 isolated from Crohn’s disease is involved in bacterial invasion of intestinal epithelial cells. Mol. Microbiol., 2001, 39, 1272-1284.

Masseret E., Boudeau J., Colombel JF., Neut C., Desreumaux P., Joly B., Cortot A., Darfeuille-Michaud A. Genetically related Escherichia coli strains associated with Crohn's disease. Gut, 2001, 48, 320-325.

Pradel N., Boukhors K., Bertin Y., Forestier C., Martin C., and Livrelli V. Heterogeneity of Shiga toxin-producing Escherichia coli strains isolated from HUS patients, cattle and food samples in central France. Appl. Environ. Microbiol., 2001, 67, 2460-2468

Forestier C., De Champs C., Vatoux C., and Joly B. Probiotic activities of Lactobacillus rhamnosus casei : in vitro adherence to intestinal cells and antimicrobial properties. Res. Microbiol., 2001, 152, 167-173.

Glasser A.L., Boudeau J., Barnich N., Perruchot M.H., Colombel J.F., and Darfeuille-Michaud A. Adherent invasive Escherichia coli strains from patients with Crohn’s disease survive and replicate within macrophages without inducing host cell death. Infect. Immun., 2001, 69, 5529-5537.

Blanquet S., Bonnin S., Beyssac E., Pompon D., Renaud M. and Alric M., The biodrug concept : An innovative approach to therapy combining genetically engineered Saccharomyces Cerevisiae and a gastro-intestinal tract model, Trends in Biotechnology, 2001, 19, (10), 393-400

Marteau, P., P. Pochart, J. Dore, C. Bera-Maillet, A. Bernalier, and G. Corthier. 2001. Comparative study of bacterial groups within the human cecal and fecal microbiota. Applied and Environmental Microbiology 67:4939-4942.

Robert, C., C. Del'Homme, and A. Bernalier-Donadille. 2001. Interspecies H2 transfer in cellulose degradation between fibrolytic bacteria and H2-utilizing microorganisms from the human colon. FEMS Microbiology Letters 205:209-214.

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2002
N. Maroncle, D. Balestrino, C. Rich, and C. Foerstier. Identification of Klebsiella pneumoniae genes involved in intestinal colonization and adhesion using signature-tagged mutagenesis. Infect. Immun., 2002, 70, 4729-34

Darfeuille-Michaud A. Adherent-invasive Escherichia coli: a putative pathogenic bacteria associated with Crohn’s disease. Int J Med Microbiol. 2002;292 : 185-193.

Blanquet S., Meunier J.P., Minekus M., Marol-Bonnin S., and Alric M., Recombinant Saccharomyces cerevisiae expressing a artificial digestive systems : a model for biodetoxication in the human digestive environment, Appl Environ Microbiol. 2003;69 : 2884-2892

Vissac, C., Lemery, D., Le Corre, L., Fustier, P., Dechelotte, P., Maurizis, J-c., Bignon YJ, Bernard-Gallon DJ. Presence of BRCA1 and BRCA2 proteins in human milk fat globules after delivery. Bioch. Biophys. Acta 2002, 1586 : 50-56.

Bernard-Gallon DJ, Vissac-Sabatier, C., Antoine-Vincent, D., Rio, PG., Maurizis, J-C, Fustier, P. & Bignon YJ. Differential effects of n-3 and n-6 polyunsaturated fatty acids on BRCA1 and BRCA2 gene expression in breast cell lines. Br. J. Nutrition 2002, 87 : 281-289.

Vissac, C., Peffault de Latour, M., Communal, Y., Bignon YJ, Bernard-Gallon DJ. Expression of BRCA1 and BRCA2 in different tumour cell lines with various growth status. Clinica Chimica Acta 2002 , 320 : 101-110.

Bernalier, A., J. Dore, and S. Rabot. 2002. Structure et fonctions métaboliques de la microflore gastro-intestinale de l'Homme. In "Aliments Fonctionnels" M. Roberfroid Ed, Lavoisier. Collection "Sciences et Techniques Alimentaires" 41-72.

Bussiere, F. I., E. Gueux, E. Rock, J. P. Girardeau, A. Tridon, A. Mazur, and Y. Rayssiguier . 2002. Increased phagocytosis and production of reactive oxygen species by neutrophils during magnesium deficiency in rats and inhibition by high magnesium concentration. British Journal of Nutrition 87:107-113.

Zimowska, W., J.P. Girardeau, J. Kuryszko, D. Bayle, Y. Rayssiguier, and A. Mazur. 2002. Morphological and imune response alterations in the intestinal mucosa of the mouse after short periods on a low-magnesium diet. British Journal of Nutrition 88(5), 515-522.

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Effets des fruits et légumes sur la santé : fractions non énergétiques des aliments

1998

Bernard-Gallon, D.J., J.C. Maurizis, P.G. Rio, Y.J. Bignon., Influence of genistein and daidzein on BRCA1 protein level in human breast cell lines. J. Natl. Cancer Inst 1998 ; 90 : 862-863.

Bernard-Gallon, D.J., J.C. Maurizis, P.G. Rio, Ph. Bougnoux, Y.J. Bignon. Effects of monounsaturated and polyunsaturated fatty acids (-3 and -6) on Brca1 protein expression in breast cell lines. J. Natl. Cancer Inst. 1998 ; 90 : 1234-1235.

Borel P., Grolier P., Boirie Y., Simonet L., Verdier E., Rochette Y., Alexandre-Gouabau M.C., Beaufrère B., Lairon D., Azais-Braesco V., 1998. Oxidative stress status and antioxidant status are apparently not related to carotenoid status in healthy subjects. J. Lab. Clin. Med. 132, 61-66.

Borel P., Grolier P., Mekki N., Boirie Y., Rochette Y., Le Roy B., Alexandre-Gouabau M.C., Lairon D., Azaïs-Braesco V., 1998. Low and high responders to pharmacological doses of b-carotene: proportion in the population, mechanisms involved and consequences on b-carotene metabolism. J. Lipid Res. 39, 2250-2260.

Borel P., Mekki N., Boirie Y., Partier A., Grolier P., Alexandre-Gouabau M.C., Beaufrère B., Portugal H., Lairon D., Azaïs-Braesco V., 1998. Comparison of the post-prandial plasma vitamin A response in young and older adults. J. Gerontol. 53A, B33-B40.

Borel P., Tyssandier V., Mekki N., Grolier P., Rochette Y., Alexandre-Gouabau M.C., Lairon D., Azaïs-Braesco V., 1998. Chylomicron ß-carotene and retinyl palmitate responses are dramatically diminished when men ingest ß-carotene with medium-chain rather than long-chain triglycerides. J. Nutr. 128, 1361-1367.

Coudray C., Bousset C., Tressol J.C., Pépin D., Rayssiguier Y., 1998. Short-term ingestion of chlorogenic or caffeic acids decreases zinc but not copper absorption in rats: utilization of stable isotopes and inductively-coupled plasma mass spectrometry. Br. J. Nutr. 80, 575-584.

Coudray C., Fairweather-Tait S., 1998. Do oligosaccharides affect intestinal absorption of calcium in humans ? Am. J. Clin. Nutr. 68, 921-923.

Demigné C., Levrat M.A., Behr S.R., Moundras C., Rémésy C., 1998. Cholesterol-lowering action of guar gum in the rat: changes in bile acids and sterols excretion and in enterohepatic cycling of bile acids. Nutr. Res. 18, 1215-1225.

Deng Z., Coudray C., Gouzou L., Mazur A., Rayssiguier Y., Pépin D., 1998. Effect of oral aluminium and aluminium citrate on blood level and short-term tissue distribution of aluminium in the rat. Biol. Trace Elements Res. 63, 139-147.

Favier M.L., Bost P.E., Demigné C., Rémésy C., 1998. The cholesterol-lowering effect of guar gum in rats is not accompanied by an interruption of bile acid cycling. Lipids 33, 765-771.

Feillet C., Roche B., Tauveron I., Bayle D., Rock E., Borel P., Rayssiguier Y., Thiéblot P., Mazur A., 1998. Susceptibility to oxidation and physicochemical properties of LDL in insulin-dependent diabetics. Atherosclerosis, 136, 405-407.

Gaumet N., Braillon P., Seibel M. J., Pointillart A., Coxam V., Davicco M.J., 1998. Influence of aging on cortical and trabecular bone response to estradiol treatment in ovariectomized rats. Gerontology 44, 132-139.

Grolier P., Borel P., Duszka C., Lory S., Alexandre-Gouabau M.C., Azaïs-Braesco V., Nugon-Baudon L., 1998. The bioavailability of of a and b-carotene is affected by gut microflora in the rat. Br. J. Nutr. 80, 199-204.

Hautekeete M.L., Dodeman I., Azaïs-Braesco V., Van den Berg K., Seynaeve C., Geerts A., 1998. Hepatic stellate cells and liver retinoid content in alcoholic liver disease in humans. Alcohol. Clin. Exp. Res. 22, 494-500.

Lopez H.W., Coudray C., Bellanger J., Younes H., Demigné C., Rémésy C., 1998. Intestinal fermentation lessens the inhibitory effects of phytic acid on mineral utilization in rats. J. Nutr. 128, 1192-1198.

Lopez H.W., Moundras C., Morand C., Demigné C., Rémésy C., 1998. Opposite fluxes of glutamine and alanine in the splanchnic area are an efficient mechanism for nitrogen sparing in rats. J. Nutr. 128, 1487-1494.

Malpuech-Brugère C., Astier C., Nowacki W., Mazur A., Rayssiguier Y., Rock E., 1998. Abnormal calcium homeostasis accounts for the exacerbated immune stress responses during experimental magnesium deficiency in the rat. Life Sciences 63, 1815-1822.

Malpuech-Brugère C., Kuryszko J., Nowacki W., Rock E., Rayssiguier Y., Mazur A., 1998. Early morphogical and immunological alterations in the spleen during magnesium deficiency in the rat. Magnesium Res. 11, 161-169.

Manach C., Morand C., Crespy V., Demigné C., Texier O., Régérat F., Rémésy C., 1998. Quercetin is recovered in human plasma as conjugated derivaties which retain antioxydant properties. FEBS Letters 426, 331-336.

Marangon K., Herbeth B., Lecomte E., Paul-Dauphin A., Grolier P., Chancerelle Y., Artur Y., Siest G., 1998. Diet, antioxidant status and smoking habits in French male adults. Am. J. Clin. Nutr. 67, 231-239.

Mazur A., Gueux E., Bureau I., Feillet-Coudray C., Rock E., Rayssiguier Y. 1998. Copper deficiency and lipoprotein oxidation. Atherosclerosis 137, 443-445.

Morand C., Crespy V., Manach C., Besson C., Demigné C., Rémésy C., 1998. Plasma metabolites of quercetin and their antioxidant properties. Am. J. Physiol. 44, R212-R219.

Pallet V., Azaïs-Braesco V., Enderlin V., Grolier P., Coustaut M., Garcin H., Higueret P., 1998. Ageing decreases retinoic acid and triiodothyronine nuclear expression in rat liver : exogenous retinol and retinoic acid differentially modulates this decreased expression. Mech. Ageing Dev. 99, 123-136.

Petitet S., Morand C., Besson C., Rémésy C., Demigné C., 1998. Effects of propionate on rat hepatocyte metabolism. J. Nutr. Biochem. 9, 652-658.

Younes H., Garleb K.A., Behr S.R., Demigné C., Rémésy C., 1998. Dietary fiber stimulates the extra-renal route of nitrogen excretion in partially nephrectomized rats. J. Nutr. Biochem. 9, 613-620.
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1999

Armand M., Pasquier B., André M., Borel P., Senft M., Peyrot J., Salducci J., Portugal H., Jaussan V., Lairon D., 1999. Digestion and absorption of 2 fat emulsions with different droplet sizes in the human digestive tract. Am. J. Clin. Nutr. 70, 1096-10106.

Bernard-Gallon, D.J., P. Dechelotte, P.G. Rio, Y.J. Bignon. BRCA1 and BRCA2 proteins are expressed in milk fat globules. Int. J. Cancer 1999 ; 81 : 839-843.

Chevalier S., Blaner W.S., Azaïs-Braesco V., Tuchweber B., 1999. Dietary restriction alters retinol and retinol-binding protein metabolism in aging rats. J. Gerontol. A Biol. Sci. Med. Sci. 54, B384-B392.

Cia D., Bonhomme B., Azim E.M., Wada A., Doly M., Azaïs-Braesco V., 1999. A reversed-phase high-performance liquid chromatographic method to analyze retinal isomers. J. Chrom. A. 864, 257-262.

Coudray C, Gaumet N, Bellanger J, Coxam V, Barlet J. P, Rayssiguier Y., 1999. Influence of age and hormonal treatment on intestinal absorption of magnesium in ovariectomised rats. Magnesium Res. 12, 109-114.

Crespy V., Morand C., Manach C., Besson C., Demigné C., Rémésy C., 1999. Part of quercetin absorbed in the small intestine is conjugated and further secreted in the intestinal lumen. Am. J. Physiol. 277, G120-G126.

Davicco M.J., Horcajada-Molteni M.N., Gaumet-Meunier N., Lebecque P., Coxam V., Barlet J.P., 1999. Endurance training and bone metabolism in old rats. Mech. Ageing Dev., 109, 83-96.

Déprez, S., A Sca1bert, 1999. [14C]-Biolabelling of (+)-catechin and proanthocyanidin oligomers in wil1ow- tree cuttings. J. Agric. Food Chem. 47, 4219-4230.

Favy, D.A., P. Rio, J.C. Maurizis, C. Hiziel, Y.J. Bignon, D.J. Bernard-Gallon. Prolactin-dependent up-regulation of BRCA1 expression in human breast cancer cell lines. Bioch. Biophys. Res. Commun. 1999 ; 258 : 284-291.

Feillet-Coudray C., Rock E., Coudray C., Grzelkowska K., Azaïs-Braesco V., Dardevet D., Mazur A., 1999. Lipid peroxidation and antioxidant status in experimental diabetes. Clin. Chim. Acta. 284, 31-43.

Feillet-Coudray C., Tourtauchaux R., Niculescu M., Rock E., Tauveron I., Alexandre-Gouabau M.C., Rayssiguier Y., Jalenques I., Mazur A., 1999. Plasma levels of 8epiPGF2a? an in vivo marker of oxidative stress, are not affected by aging or Alzheimer's disease. Free Rad. Biol. Med. 27, 463-469.

Ghyselinck N.B., Bavik C., Sapin V., Mark M., Bonnier D., Hindelang C., Dierich A., Nilsson C.B., Hakansson H., Sauvant P., Azaïs-Braesco V., Frasson M., Picaud S., Chambon P., 1999. Cellular Retinol Binding Protein I is essential for vitamin A homeostasis. EMBO J. 18, 4903-4914.

Hizel, C., J.C. Maurizis, P. Rio, Y. Communal, J. Chassagne, D. Favy, Y.J. Bignon, D.J. Bernard-Gallon. Isolation, purification and quantification of BRCA1 protein from tumour cells by affinity perfusion chromatography. J. Chrom. B 1999 ; 721 : 163-170.

Horcajada-Molteni M.N., Davicco M.J., Coxam V., Lebecque P., Dominguez B., Ritz P., Culioli J., Barlet J.P., 1999. Treadmill running starting three months after orchidectomy restores femoral bone mass in rats. Eur. J. Appl. Physiol. 79, 251-259.

Horcajada-Molteni M.N., Davicco M.J., Collignon H., Lebecque P., Coxam V., Barlet J.P., 1999. Does endurance running before orchidectomy prevent osteopenia in rats ? Eur. J. Appl. Physiol. 80, 344-352.

Laurant P., Dalle M., Berthelot A., Rayssiguier Y., 1999. Time-course of the change in blood pressure level in magnesium-deficient Wistar rats. Br. J. Nutr. 82, 243-251.

Levrat-Verny M.A., Coudray C., Bellanger J., Lopez H.W., Demigné C., Rayssiguier Y., Rémésy C., 1999. Wholewheat flour ensures higher mineral absorption and bioavailability than white wheat flour in rats. Br. J. Nutr. 82, 17-21.

Lopez W.H., Levrat M.A., Guy C., Messager A., Demigné C., Rémésy C., 1999. Effects of soluble corn bran arabinoxylans on cecal digestion, lipid metabolism and mineral balance (Ca, Mg) in rats. J. Nutr. Biochem. 10, 500-509.

Malpuech-Brugère C., Nowacki W., Gueux E., Kuryszko J., Rock E., Rayssiguier Y., Mazur A., 1999. Accelerated thymus involution in magnesium-deficient rats is related to the enhanced apoptosis and sensitivity to oxidative stress. Br. J. Nutr. 81, 405-411.

Malpuech-Brugère C., Nowacki W., Rock E., Gueux E., Mazur A., Rayssiguier Y., 1999. Enhanced tumor necrosis factor-a production following endotoxin challenge in rats is an early event during magnesium deficiency. Biochim. Biophys. Acta 1453, 35-40.

Manach C., Texier O., Morand C., Crespy V., Régérat F., Demigné C., Rémésy C., 1999. Comparison of the bioavailability of quercetin and catechin in rats. Free Rad. Biol. Med 27, 1259-1266.

Mazur A., Bayle D., Lab C., Rock E., Rayssiguier Y., 1999. Inhibitory effect of procyanidin-rich extracts on LDL oxidation in vitro. Atherosclerosis 145, 421-422.

Mekki N., Christofilis A., Charbonnier M., Atlan-Gepner C., Defoort C., Juhel C., Borel P., Portugal H., Pauli A.M., Vialettes B., Lairon D., 1999. Influence of obesity and body fat distribution on postprandial lipemia and triglyceride-rich lipoproteins in adult women. J. Clin. Endocrinol. Metab. 84, 184-191.

Vernet P., Rock E., Mazur A., Rayssiguier Y., Dufaure J. P., Drevet J., 1999. The selenium-independent epidydimis-restricted glutathione peroxidase 5 protein (GPX5) can back-up failing Se-dependent GPXs in mice subjected to selenium deficiency. Mol. Reprod. Dev. 54, 362-370.

Younes H., Alphonse J.C., Behr S.R., Demigné C., Rémésy C., 1999. Role of fermentable carbohydrate supplements with a low-protein diet in course of chronic renal failure: Experimental bases. Am. J. Kidney Dis. 33, 633-646.

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2000

Azaïs-Braesco V., Pascal G. (2000). Vitamin A in pregnancy : requirements and safety limits. Am. J. Clin. Nutr. 71, 1325S-1333S.

Azaïs-Braesco V., Winklhoffer-Roob B., Ribalta J., Hanley B., Vasson MP, Brtko J, Brigeluis-Flohe R, Bronner A., 2000. Vitamin A, vitamin E and carotenoid status and metabolism during ageing: functional and nutritional consequences (VITAGE project proposal). Endocr. Regul. 34, 97-98.

Begon S, Pickering G, Eschalier A, Dubray C, 2000. Magnesium and MK-801 have a similar effect in two experimental models of neuropathic pain. Brain Research 2000 887, 436-439.

Coudray C., Favier A., 2000. Determination of salicylate hydroxylation products as an in vivo oxidative stress marker. Free Radic. Biol. Med. 29(11), 1064-1070.

Coudray C, Tressol JC, Feillet-Coudray C, Bellanger J, Pépin D, Mazur A, 2000. Long-term consumption of red wine does not modify intestinal absorption and status of zinc and copper in rats. J. Nutr.130, 1309-1313.

Deng Z., Coudray C., Gouzoux L., Mazur A., Rayssiguier Y., Pépin D., 2000. Effects of acute and chronic coingestion of A1Cl3 with citrate orpolypphenolic acids on tissue retention and distribution of Aluminum in rats. Biol. Trace Elem. Res. 76(3), 245-256.

Déprez, S., C. Brézillon, S. Rabot, C. Philippe, I. Mila, C. Lapierre, A. Scalbert, 2000. Polymeric proanthocyanidins are catabolized by a human colonic microflorn into low molecuJar weight phenolic acids. J. Nutr. 130, 2733-2738.

Favy, D.A., S. Lafarge, P. Rio, C. Vissac, Y.J. Bignon, D. Bernard-Gallon. Real-time PCR quantification of full-length and exon 11 spliced BRCA1 transcripts in human breast cancer cell lines. Biochemica and Biophysica Research Communications 2000 ; 274 : 73-78.

Favy, D.A., P.G. Rio, C. Vissac, J.C. Maurizis, Y.J. Bignon, D.J. Bernard-Gallon.Cyclosporine A inhibition of prolactin-dependent up-regulation of BRCA1 protein expression in human breast cell lines. Anticancer Research 2000 ; 20 :1703-1704.

Feillet-Coudray C., Coudray C., Bayle D., Rock E., Rayssiguier Y., Mazur A. (2000). Response of diamine oxidase and other plasma copper biomarkers to various dietary copper intakes in the rat and evaluation of copper absorption with a stable isotope. Br. J. Nutr. 83, 561-568.

Feillet F, Feillet-Coudray C, Bard JM, Parra HJ, Favre E (2000). Plasma cholesterol and endogenous cholesterol synthesis during refeeding in anorexia nervosa. Clinica Chimica Acta 294, 45-56.

Feillet-Coudray C, Coudray C, Bayle D, Rock E, Rayssiguier Y, Mazur A (2000). Response of diamine oxidase and other plasma copper biomarkers to various dietary copper intakes in the rat and evaluation of copper absorption with a stable isotope. Br. J. Nutr. 83, 561-568.

Feillet-Coudray C, Coudray C, Gueux E, Ducros V, Mazur A, Abrams S, Rayssiguier Y (2000). Compartmental analysis of magnesium kinetics in Mg-sufficient and Mg-deficient rats. Metabolism 49, 1326-1329.

Feillet-Coudray C, Coudray C, Brûlé F, Gueux E, Mazur A, Abrams S, Rayssiguier Y., 2000. Exchangeable magnesium pool masses reflect the magnesium status of rats. J. Nutr. 130, 2306-2311.

Felgines C., Texier O., Morand C., Manach C., Scalbert A., Régérat F., Rémésy C., 2000. Bioavailability of the flavanone naringenin and its glycosides in rats. Am. J. Physiol. (Gastrointest Liver Physiol) 279, G1148-G1154.

Gatellier P., Mercier Y., Rock E., Renerre M., 2000. Influence of dietary fat and vitamin E supplementation on free radical production and on lipid and protein oxidation in turkey muscle extracts. J. Agric. Food Chem. 48, 1427-1433.

Gaumet-Meunier N., Coxam V., Robins S., Pastoureau P., Pointillart A., Davicco M.J., Lebecque P., Barlet JP, 2000. Gonadal steroids and bone metabolism in young castrated male rats. Calcif. Tissue Int., 66,470-475.

Grolier P., Boirie Y., Levadoux E., Brandolini M., Borel P., Azaïs-Bresco V., Beaufrère B., Ritz P., 2000. Age-related changes in plasma lycopene concentrations, but not in vitamin E are associated with fat-mass. Br. J. Nutr. 84, 711-716.

Horcajada-Molteni M.N., Davicco M.J., Lebecque P., Coxam V., Young A.A., Barlet J.P., 2000. Amylin inhibits ovariectomy-induced bone loss in rats. J. Endocr, 165,663-668.

Horcajada-Molteni M.N., Crespy V., Coxam V., Davicco M.J., Rémésy C., Barlet J.P., 2000. Rutin inhibits ovariectomy-induced osteopenia in rats. J. Bone Miner. Res., 15(11) 2251-2258.

Levrat-Verny M.A., Behr S., Mustad V., Rémésy C., Demigné C., 2000. Low levels of viscous hydrocolloids lower plasma cholesterol in rats primarily by impairing cholesterol absorption. J. Nutr. 130, 243-248.

Lopez H.W., Coudray C, Bellanger J, Levrat-Verny MA, Demigné C, Rayssiguier Y, Rémésy C, 2000. Resistant starch improves mineral assimilation in rats adapted to a wheat bran diet. Nutr Res. 20, 141-155.

Lopez HW, Vallery F, Levrat-Verny MA, Coudray C, Demigné C, Rémésy C, 2000. Dietary phytic acid and wheat bran enhance mucosal phytase activity in rat small intestine. J. Nutr. 130, 2020-2025.

Lopez H.W., Ouvry A., Bervas E., Guy C., Messager A., Demigné C., Rémésy C., 2000. Strains of lactic acid bacteria isolated from sour doughs degrade phytic acid and improve calcium and magnesium solubility from whole wheat flour. J. Agric. Food Chem. 48, 2281-2285.

Lopez HW, Coudray C., Levrat-Verny MA., Feillet-Coudray C., Demigné C;, Rémésy C., 2000. Fructooligosaccharides enhance mineral apparent absorption and counteract the deleterious effects of phytic acid on mineral homeostasis in rats. J. Nutr. Biochem. 10, 500-508.

Malpuech-Brugère C., Nowacki W., Daveau M., Gueux E., Linard C., Rock E., Lebreton J.P., Mazur A., Rayssiguier Y., 2000. Inflammatory response following acute magnesium deficiency in the rat. Biochim. Biophys. Acta 1501, 91-98.

Morand C., Manach C., Crespy V., Rémésy C., 2000. Quercetin-3-O-bêta glucoside is better absorbed than other quercetin forms and is not present in rat plasma. Free Radic. Res. 33, 667-676.

Morand C., Manach, C., Crespy, V., Remesy C., 2000, Respective bioavailability of quercetin aglycone and its glycosides in a rat model. BioFactors, 12, 169-174.

Moriceau S., Besson C., Levrat M.A., Moundras C., Rémésy C., Morand C., Demigné C., 2000. Cholesterol-lowering effects of guar gum : Changes in bile acid pools and intestinal reabsorption. Lipids 35, 437-444.

Nilsson CB, Hoegberg P, Trossvik C, Azaïs-Braesco V, Blaner WS, Fex G, Harrison EH, Nau H, Schmidt CK, van Bennekum AM, Hakansson H., 2000. 2,3,7,8-Tetrachlorodibenzo-p-dioxin increases serum and kidney retinoic acid levels and kidney retinol esterification in the rat. Toxicol. Appl. Pharmacol. 169, 121-131.

Picherit C., Coxam V., Bennetau-Pelissero C., Kati-Coulibaly S., Davicco M.J., Lebecque P., Barlet J.P. (2000). Daidzein is more efficient than genistein in preventing ovariectomy-induced bone loss in rats. J. Nutr. 130, 1675-1681.

Picherit C., Coxam V., Oudadesse H., Martini B., Gaumet N., Davicco M.J., Lebecque P., Miller S., Irrigaray J.L., Barlet J.P., 2000. Dihydrotestosterone prevents glucocorticoid-negative effects on fetal rat metatarsal bone in vitro. Biol. Neonate 77, 181-190.

Picherit C., Dalle M., Neliat G., Lebecque P., Davicco M.J., Barlet J.P., Coxam V., 2000. Genistein and daidzein modulate in vitro rat uterine contractile activity. J. Steroid Biochem. Mol. Biol. 75, 201-208.

Pointillart A., Coxam V., Seve B., Colin C., Lacroix C.H., Gueguen L., 2000. Bioavailability of calcium from skim milk, calcium sulfate and calcium carbonate for bone mineralization using pig as animal model. Reprod. Nutr. Dévelop. 40,49-61.

Rock E., Kehoe C., Mazur A., O'Connor J.M., Bonham M.P., Rayssiguier Y., Strain J.J., 2000. The effect of copper supplementation on red blood cell oxidizability and plasma antioxidants in middle-aged healthy volunteers. Free Rad. Biol. Med. 28, 324-329.

Sapin V., Alexandre-Gouabau M.C., Chaib S., Bournazeau J.A., Sauvant P., Deret S., Borel P., Jacquetin B., Grolier P., Lemery D., Dastugue B., Azaïs-Braesco V., 2000. Effect of vitamin A status at the end of term pregnancy, on the saturation of retinol binding protein with retinol. Am. J. Clin. Nutr. 71, 537-543.

Sapin V., Chaib S., Blanchon L., Alexandre-Gouabau M.C., Lemery D., Charbonne F., Gallot D., Jacquetin B., Dastugue B., Azaïs-Braesco V., 2000. Esterification of vitamin A by the human placenta involves villous mesenchymal fibroblasts. Pediatric Research 48(4), 565-572.

Sebedio, J. L., Vermunt, S. H., Chardigny, J. M., Beaufrere, B., Mensink, R. P., Armstrong, R. A., Christie, W. W., Niemela, J., Henon, G. and Riemersma, R. A. (2000) The effect of dietary trans alpha-linolenic acid on plasma lipids and platelet fatty acid composition: the TransLinE study. Eur J Clin Nutr. 54, 104-13.

Steghens J.P., Lyan B., Le Moel G., Galabert C., Fayol V., Faure H., Grolier P., Cheribi N., Dubois F., Nabet F., 2000. Dosages des caroténoides par chromatographie liquide haute performance : des difficultés aux solutions. Ann. Biol. Clin., 58, 327-335.

Tahiri M, Pellerin P, Tressol JC, Doco T, Pépin D, Rayssiguier Y, and Coudray C. (2000). The rhamnogalacturonan-II dimer, present in fruits and vegetables, decreases intestinal absorption and tissue accumulation of lead in the rat. J Nutr. 130, 249-253.

Turley E., McKeown A., Bonham M.P., O'Connor J.M., Chopra M., Harvey L., Majsak-Newman G., Fairweather-Tait S.J., Bugel S., Sandstrom B., Rock E., Mazur A., Rayssiguier Y., Strain J.J., 2000 Copper supplementation in humans does not affect the susceptibility of low density lipoprotein to in vitro oxidation (FOODCUE project). Free Rad. Biol. Med. 29, 1129-1134.

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2001

Adam A., Levrat-Verny MA., Lopez HW., Leuillet M., Demigné C., Rémésy C., 2001. Whole wheat and triticale flours with differing viscosities stimulate cecal fermentations and lower plasma and hepatic lipids in rats. J. Nutr. 131, 1770-1776.

Aubel C, Dehez S, Chabanon H, Seva C, Ferrara M, Brachet P. Activation of c-Jun N-terminal kinase 1 (JNK-1) after amino acid deficiency in HeLa cells. Cell Signal. 2001 Jun;13(6):417-23.

Begon S, G Pickering, A Eschalier, A Mazur, Y Rayssiguier, C Dubray. Implication of spinal NMDA receptors protein kinase C and nitric oxide synthetase in the hyperalgesia induced by magnesium deficiency in rats. Brt J Pharmacol ., 2001, 134, 1227-1236.

Borel P., Armand M., Pasquier B., Tyssandier V., Grolier P., Alexandre-Gouabau M.C., Peyrot J., Jaussan V., Lairon D., Azaïs-Braesco V., 2001. Processing of Vitamin A and E in the Human Gastrointestinal Tract. Am. J. Physiol. 280, G95-G103.

Borel P, Pasquier B, Armand M, Tyssandier V, Grolier P, Alexandre-Gouabau MC, Andre M, Senft M, Peyrot J, Jaussan V, Lairon D, Azais-Braesco V. Processing of vitamin A and E in the human gastrointestinal tract. Am J Physiol Gastrointest Liver Physiol. 2001 Jan;280(1):G95-G103.

Coudray C, Levrat-Verny MA, Tressol JC, Feillet-Coudray C, Horcajada-Molteni MN, Demigné C, Rayssiguier Y, Rémésy C, 2001. Mineral supplementation of white wheat flour is necessary to maintain adequate mineral status and bone characteristics in rats. J. Trace Elem. Med. Biol. 15, 131-137.

Choubert G, Guillou A, Tyssandier V, Borel P, Grolier P .2001. Valeur santé des caroténoïdes. Science des Aliments, 21: 467-480.

Crespy V., Morand C., Besson C., Manach C., Demigné C., Rémésy C., 2001. Comparison intestinal metabolism of quercetin and phloretin, and their glucosides in rats. J. Nutr. 131, 2109-2114.

Dangles O., Dufour C., Manach C., Morand C., Rémésy C., 2001. Binding of flavonoids to plasma proteins. Methods Enzymol. 335, 319-333.

Déprez, S., I. Mila, J.-F. Huneau, D. Tomé, A Scalbert, 2001. Transport of proanthocyanidin dimer, trimer and polymer across monolayers of human intestinal epithelial Caco-2 ce1ls. Antiox. Redox. Signa1. 3, 957-967.

Donovan J., Crespy V., Manach C., Morand C., Besson C., Scalbert A., Rémésy C., 2001. Catechin is metabolized by both the small intestine and the liver in rats. J. Nutr. 131, 1753-1757.

Horcajada-Molteni M.N., Chanteranne B., Lebecque P., Davicco M.J., Coxam V., Young A.A., Barlet J.P., 2001. Amylin and bone metabolism in streptozotocin-induced diabetic rats. J. Bone Min. Res. 16, 958-965.

Lopez H.W., Krespine V., Guy C., Messager A., Demigné C., Rémésy C., 2001. Prolonged fermentation of whole wheat sourdough reduces phytate level and increases soluble magnesium. J. Agric. Food Chem. 49, 2657-2662.

Lopez HW., Levrat-Verny MA., Coudray C., Besson C., Krespine V., Messager A., Demigné C., Rémésy C., 2001. Class 2 resistant starches lower plasma and liver lipids and improve mineral retention in rats.J. Nutr. 131, 1283-1289.

Lyan B., Azaïs-Braesco V., Cardinault N., Tyssandier V., Borel P., Alexandre-Gouabau M.C., Grolier P., 2001. Simple method for clinical determination of 13 carotenoids in human plasma using an isocratic high-performance liquid chromatographic method. J. Chrom. B, 751, 297-303.

Morand C., Manach C., Donovan J., Rémésy C., 2001. Preparation and characterization of flavonoid metabolites present in biological samples. Methods Enzymol. 335, 115-121.

Picherit C., Bennetau-Pelissero C., Chanteranne B., Lebecque P., Davicco M.J., Barlet J.P., Coxam V., 2001. Soybean isoflavones dose-dependently reduce bone turnover but do not reverse established osteopenia in adult ovariectomized rats. J. Nutr. 131, 723-728.

Picherit C., Chanteranne B., Bennetau-Pelissero C., Davicco M.J., Lebecque P., Barlet J.P., Coxam V., 2001. Dose-dependent bone-sparing effects of dietary isoflavones in the ovariectomized rat. Br. J. Nutr. 85, 307-316.

Rock E, Winklhofer-Roob BM, Ribalta J, Scotter M, Vasson MP, Brtko J, Brigelius-Flohe R, Bronner A, Azais-Braesco V. Vitamin A, vitamin E and carotenoid status and metabolism during ageing: functional and nutritional consequences (VITAGE PROJECT). Nutr Metab Cardiovasc Dis. 2001;11:70-73.

Sauvant P., Sapin V, Alexandre-Gouabau MC, Dodeman I, Delpal S, Quadro L, Partier A, Abergel A, Colantuoni V, Rock E, Azais-Braesco V : Retinol mobilization from cultured rat hepatic stellate cells does not require retinol binding protein synthesis and secretion. Int. J. Biochem Cell B, 2001, 33 :1000-1012.

Tahiri M, Tressol JC, Doco T, Rayssiguier Y, Coudray C., 2001. Chronic oral administration of rhamnogalacturonan-II dimmer, a pectic polysaccharide, failed to accelerate lead organism decorporation after chronic lead exposure in rats. Br J Nutr 87, 47-54.

Tyssandier V, Lyan B, Borel P. 2001. Main factors governing the transfer of carotenoids from emulsion lipid droplets to micelles. Biochim Biophys Acta., 31; 1533: 285-292.

Tyssandier V., Cardinault N., Caris-Veyrat C., Amiot M.J., Grolier P., Bouteloup C., Azaïs-Braesco V., Borel P., 2001. Vegetable-lutein, lycopene and beta-carotene compete which each other for their incorporation in chylomicrons, but this has no adverse effect on the medium term (3 weeks) plasma status of carotenoids in humans. Am. J. Clin. Nutr. 75, 526-534.

Younes H., Alphonse JC., Hadj-Abdelkader M., Rémésy C., 2001. Fermentable carbohydrate and digestive nitrogen excretion. J. Ren. Nutr. 11, 139-148.

Younes H., Coudray C., Bellanger J., Demigné C., Rayssiguier Y., Rémésy C., 2001. Effects of two fermentable carbohydrates (inulin and resistant starch) and their combination on calcium and magnesium balance in rats. Br. J. Nutr. 86(4), 479-485.

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2002

Begon S, A Alloui, A Eschalier, A Mazur, Y Rayssiguier, C Dubray. Assesssment of relationship between hyperalgesia and peripherical inflammation in magnesium-deficient rats. Life Science, 2002, 70, 1053-1063.

Begon S, G Pickering, A Eschalier, C Dubray. Magnesium increases morphine analgesic effect in different experimental models of pain. Anesthesiology, 2002, 96(3), 627-632.

Blanchon L Sauvant P, Bavik C, Gallot D, Charbonne F, Alexandre-Gouabau MC, Lemery d, Jacquetin B, Dastugue B, Ward S, Sapin V: Human choriocarcinoma cell line JEG-3 produces and secretes active retinoïds from retinol. Mol Hum Reprod, 2002, 8:485-493.

Busserolles J, Rock E, Gueux E, Mazur A, Grolier P, Rayssiguier Y. 2002. Short-term consumption of a high-sucrose diet has a pro-oxidant effect in rats. Br J Nutr., 87:337-342.

Chabanon, L. Persson, H.M. Wallace, M. Ferrara, P. Brachet. 2002. Increased translation efficiency and antizyme-dependent stabilisation of ornithine decarboxylase in amino acid-supplemented human colon adenocarcinoma cells, Caco-2. Biochem. J. 348, 401-408.

Coudray C, Feillet-Coudray C, Grizard D, Tressol JC, Gueux E, Rayssiguier Y, 2002. Fractional intestinal absorption of magnesium is directly proportional to dietary magnesium intake inr ats. J. Nutr. 132, 2043-2047.

Donovan JL, Manach C, Rios L, Morand C, Scalbert A, Rémésy C, 2002. Procyanidins are not bioavailable in rats fed a single meal containing a grape seed extract or the procyanidin dimer B3. Brit. J. Nutr. 87, 299-306.

Donovan JL, Crespy C, Manach C, Morand C, Besson C, Scalbert A, Rémésy C, 2002. Catechin is metabolized by both the small intestine and the liver in rats. J. Nutr. 131, 1753-1757.

Feillet-Coudray C, Coudray C, Tressol JC, Pepin D, Mazur A, Abrams SA & Rayssiguier Y (2002) Exchangeable magnesium pool masses in healthy women: effects of magnesium supplementation. Am J Clin Nutr. 75(1):72-8.

Felgines C, Texier O, Besson C, Fraisse D, Lamaison JL, Rémésy C. Blackberry anthocyanins are slightly bioavailable in rats. J Nutr 2002 132(6) 1249-1253

Gerber M, Bourton-Ruault MC, Hercberg S, Riboli E, Scalbert A, Siess MH, 2002. Actualités en cancérologie: fruits, légumes et cancers. Bull. Cancer 89, 293-312.

Sapin V, Marceau G, Jacomet C, Boniol C, Cormerai L, Lairichesse H, Dastugue B, Beytout J, Boespflug-Tanguy O : Hyperlactatemia and HIV-infected patients with nucleoside analog reverse-transcriptase inhibitors treatment : the Clermont HIV cohort study. In : Mitochondrial disorders from pathophysiology to acquired defects, C. Desnuelle and S. DiMauro, Springer-Verlag France 2002, pp 153-160.

Sauvant P, Sapin V, Abergel A , Carsten K, Schmidt CK, Blanchon L, Alexandre-Gouabau MC, Rosenbaum J, Bommelaer G, Rock E, Dastugue B, Nau H, Azais-Braesco V : PAV-1 , a new rat hepatic stellate cell line converts retinol into retinoïc acid, a process altered by ethanol. INT J Biochem & Cell Biol , 2002, 34 :1017-1029.

Scalbert A, Morand C, Manach C, Rémésy C, 2002. Absorption and metabolism of polyphenols in the gut and impact on health. Biomed. Pharmacother. 56, 269-316.

Tarrerias AL, M Millecamps, A Alloui, C Beaughard, J.L Kemeny, S Bourdu, G Bommelaer, A Eschalier, M Dapoigny, D Ardid. Short-chain fatty acides enemas fail to decrease colonic hypersensitivity and inflammation in TNBS-induced colonic inflammation in rats. Pain, 2002, 100, 91-97

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Métabolisme protéino-énergétique et vieillissement

1998
Balage, M., Larbaud, D., Debras, E., Hocquette, J. F. and Grizard, J. (1998) Acute hyperinsulinemia fails to change glut-4 content in crude membranes from goat skeletal muscles and adipose tissue. Comp. Biochem. Physiol. 120, 425-430

Boirie Y, Beaufrère B., 1998. Protéines lentes ou rapides : attention à la vitesse ! Métabolismes-Hormones-Nutrition, 2, 38-40

Comité de Nutrition de la Société Française de Pédiatrie (participation de B. Beaufrère), 1998. Besoins en protéines et en énergie de l'enfant atteint de malnutrition sèvre. Application au traitement en milieu hospitalier de la malnutrition par carence d'apports. Arch. Pédiatr., 5, 763-771.

Borel, P., Grolier, P., Boirie, Y., Simonet, L., Verdier, E., Rochette, Y., Alexandre-Gouabeau, M. C., Beaufrère, B., Lairon, B. and Azais-Braesco, V. (1998) Oxidative stress status and antioxidant satus are apparently not related to the carotenoid status in healthy subjects. J. Lab. Clin. Med. 132, 61-66

Borel, P., Mekki, N., Boirie, Y., Partier, A., Alexandre-Gouabeau, M. C., Grolier, P., Beaufrère, B., Portugal, H., Lairon, D. and Azais-Braesco, V. (1998) Comparison of the post prandial plasma vitamin A response in young and older adults. J. Gerontol. A. Biol. Sci. Med. Sci. 53A, B133-B140

Bouteloup-Demange, C., Boirie, Y., Dechelotte, P., Gachon, P. and Beaufrère, B. (1998) Gut mucosal protein synthesis in fed and fasted human. Am. J. Physiol. Endocrinol. Metab. 274, E541-E546

Brachet, P., Long, J. E. and Seidel, E. R. (1998) Selective sites for polyamine binding to rabbit intestinal brush-border membranes. Biochem. Pharmacol. 56, 517-526

Breuillé, D., Arnal, M., Rambourdin, F., Bayle, G., Levieux, D. and Obled, C. (1998) Sustained modifications of protein metabolism in various tissues in a rat model of long- lasting sepsis. Clin. Sci. 94, 413-423

Castiglia-Delavaud, C., Verdier, E., Besle, J. M., Vernet, J., Boirie, Y., Beaufrère, B., de Baynast, R. and Vermorel, M. (1998) Net energy value of non-starch polysaccharide isolates (sugarbeet fibre and commercial inulin) and their impact on nurient digestive utilization in helathy human subjects. Br. J. Nutr. 80, 343-352

Cosnes J., Beaufrère B., 1998. Optimizing protein synthesis through enteral diets. Editorial comments. Nutrition, 14, 311-312

Dardevet, D., Sornet, C., Savary, I., Debras, E., Patureau Mirand, P. and Grizard, J. (1998) Glucocorticoid effects on insulin- and IGF-I- regulated muscle protein metabolism during aging. J. Endocrinol. 156, 83-89

De Bandt, J. P., Blondé-Cynober, F., Bories, P. N., Cassereau, C., Cynober, L., Devanlay, M., Le, B. J., Minet-Quinard, R., Pailla, K., Vasson, M. P. and Villié, F. (1998) Les modifications de la sensibilité aux hormones au cours du vieillissement : conséquences métaboliques et nutritionnelles. Nutr. Clin. Metab. 12, 161-186

Farges, M. C., Raul, F., Cézard, J. P., Davot, P., Meunier, M. T., Cynober, L. and Vasson, M. P. (1998) A pancreatic extract-enriched diet corrects ileal mucosa atrophy in endotoxemic aged rats. Dig. Dis. Sci. 43, 2244-2250

Faure, M., Hayes, H., Bledsoe, R. K., Hutson, S. and Papet, I. (1998) Assignment of the gene of mitochondrial branched chain aminotransferase (BCAT2) to sheep chromosome band 14q24 and to cattle and goat chromosome bands 18q24 by in situ hybridization. Cytogen. Cell Gen. 83, 96-97

Felgines, C., Savanovitch, C., Farges, M. C., Davot, P., Cynober, L. and Vasson, M. P. (1998) Protein metabolism in rats during long-term dietary restriction: influence of aging. J. Parenter. Enter. Nutr. 23, 32-37

Ghoos, Y., Beaufrère, B., Dangin, P., Boirie, Y., Fauquant, J., Evenepoel, P., Geypens, B., Hiele, M. and Rutgeerts, P. (1998) The production of milk and egg proteins, enriched with stable isotopes, for the in vivo study of protein assimilation and metabolism during feeding - an European Collaborative Study. Gut 43 (suppl 3), S23-S24

Hizel, C., Ferrara, M., Cure, H., Pezet, D., Dechelotte, P., Chipponi, J., Rio, P., Bignon, Y. J. and Bernard-Gallon, D. (1998) Evaluation of the 5' spliced form of human cathepsin B mRNA in colorectal mucosa and tumors. Oncol. Rep. 5, 31-34
63. Jousse, C., Bruhat, A., Ferrara, M. and Fafournoux, P. (1998) Physiological concentration of amino acids regulates insulin-like-growth-factor-binding protein 1 expression. Biochem. J. 334, 147-153

Laurichesse, H., Tauveron, I., Gourdon, F., Cormerais, L., Champredon, C., Charrier, S., Rochon, C., Lamain, S., Bayle, G., Laveran, H., Thiéblot, P., Beytout, J. and Grizard, J. (1998) Threonine and methionine are limiting amino acids for protein synthesis in patients with AIDS. J. Nutr. 128, 1342-1348

Malmezat, T., Breuillé, D., Pouyet, C., Patureau Mirand, P. and Obled, C. (1998) Metabolism of cysteine is modified during the acute phase of sepsis in rats. J. Nutr. 128, 97-105

Meynial-Denis, D., Foucat, L., Mignon, M., Chavaroux, A., Prugnaud, J., Bayle, G., Renou, J. P. and Arnal, M. (1998) Despite similar rates of alanine release, fasting and diabetes affect de novo alanine synthesis differently. Diabetologia 41, 606-608

Meynial-Denis, D., Mignon, M., Foucat, L., Bielicki, G., Ouali, A., Tassy, C., Renou, J. P., Grizard, J. and Arnal, M. (1998) pH is regulated differently by glucose in skeletal muscle from fed and starved rats : a study using 31P-NMR spectroscopy. J. Nutr. 128, 28-34

Morio, B., Montaurier, C., Pickering, G., Ritz, P., Fellmann N., Coudert, J., Beaufrère, B. and Vermorel, M. (1998) Effects of 14 weeks of progressive endurance training on energy expenditure in elderly people. Br. J. Nutr. 80, 511-519

Ritz, P., Acheson, K. J., Gachon, P., Vico, L., Bernard, J., Alexandre, C. and Beaufrère, B. (1998) Energy and substrate metabolism during a 42-day bed-rest in a head-down tilt position in humans. Eur. J. Appl. Physiol. 78, 308-314

Savary, I., Debras, E., Dardevet, D., Sornet, C., Capitan, P., Prugnaud, J., Patureau Mirand, P. and Grizard, J. (1998) Effect of glucocorticoid excess on skeletal muscle and heart protein synthesis in adult and old rats. Br. J. Nutr. 79, 297-304

Tournu, C., Obled, A., Roux, M. P., Deval, C., Ferrara, M. and Béchet, D. (1998) Glucose Controls Cathepsin Expression in Ras-Transformed Fibroblasts. Arch. Biochem. Biophys. 360, 15-24

Vary, T. C., Dardevet, D., Grizard, J., Voisin, L., Buffière, C., Denis, P., Breuillé, D. and Obled, C. (1998) Differential regulation of skeletal muscle protein turnover by insulin and IGF-I after bacteremia. Am. J. Physiol. 275, E584-E593

Vasson, M. P., Farges, M. C., Sarret, A. and Cynober, L. (1998) Free amino acid concentrations in milk: Effects of microwave versus conventional heating. Amino Acids 15, 385-388

Vidal, V., Bay, J. O., Champomier, F., Grancho, M., Beauville, L., Glowaczower, C., Lemery, D., Ferrara, M. and Bignon, Y. J. (1998) The 1396del A Mutation and a Missense Mutation or a Rare Polymorphism of the WRN Gene Detected in a French Werner Family With a Severe Phenotype and a Case of an Unusual Vulvar Cancer. Hum. Mut. 11, 413-414

Voisin, L., Breuillé, D., Ruot, B., Rallière, C., Rambourdin, F., Dalle, M. and Obled, C. (1998) Cytokine modulation by PX differently affects specific acute phase proteins during sepsis in rats. Am. J. Physiol. 275, R1412-R1419

Wells, J. C. K., Ritz, P., Davies, P. S. W. and Coward, W. A. (1998) Factors affecting the 2H to 18O dilution space ratio in infants. Pediatr. Res. 43, 467-471

Zarrabian, S., Attaix, D., Macry, J., Biou, D., Mendy, F., Roger, L. and Cézard, J. P. (1998) Effects of alimentary whole proteins versus their small peptide hydrolysates: on liver and skeletal muscle during the acute inflammation phase in the rat. Clin. Nutr. 17, 169-176

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1999
Arnal, M. A., Mosoni, L., Boirie, Y., Houlier, M. L., Morin, L., Verdier, E., Ritz, P., Antoine, J. M., Prugnaud, J., Beaufrère, B. and Patureau Mirand, P. (1999) Protein pulse feeding improves protein retention in elderly women. Am. J. Clin. Nutr. 69, 1202-1208

Aubel, C., Chabanon, H., Persson, L., Thiman, L., Ferrara, M. and Brachet, P. (1999) Antizyme-dependent and -independent mechanisms are responsible for increased spermidine transport in amino acid-restricted human cancer cells. Biochem. Biophys. Res. Commun. 256, 646-651

Belkebir-Mesbah, D., Bonnefont-Rousselot, D., Frey-Fressart, V., Moinard, C., Delattre, J. and Vasson, M. P. (1999) Consequences of a treatment with dexamethasone in rats on the susceptibility of total plasma and isolated lipoprotein fractions to copper oxidation. Endocrine 10, 233-242

Breuillé, D., Voisin, L., Contrepois, M., Arnal, M. and Obled, C. (1999) A sustained rat model for studying long-lasting catabolic state of sepsis. Infect. Immun. 67, 1079-1085

Capitan, P., Malmezat, T., Breuillé, D. and Obled, C. (1999) Gas chromatographic-mass spectrometric analysis of stable isotopes of cysteine and glutathione in biological samples. J. Chromatogr. B 732, 127-135

Chambon-Savanovitch, C., Farges, M. C., Raul, F., Blachier, F., Davot, P., Cynober, L. and Vasson, M. P. (1999) Can a glutamate-enriched diet counteract glutamine depletion in endoxemic rats? J. Nutr. Biochem. 10, 331-337

Chambon-Savanovitch, C., Felgines, C., Farges, M. C., Pernet, P., Cézard, J. P., Raul, F., Cynober, L. and Vasson, M. P. (1999) Severe dietary restriction initiated in aged rats: evidence for poor adaptation. Eur. J. Clin. Invest. 29, 504-511

Chambon-Savanovitch, C., Felgines, C., Farges, M. C., Raul, F., Cézard, J. P., Davot, P., Vasson, M. P. and Cynober, L. (1999) In search of inert nitrogen: metabolic and nutritional effects of a diet enriched with glycine, alanine or casein in endotoxemic rats. J. Nutr. 129, 1866-1870

Combaret, L., Rallière, C., Taillandier, D., Tanaka, K. and Attaix, D. (1999) Manipulation of the ubiquitin-proteasome pathway in cachexia pentoxifylline supresses the activation of 20S and 26S proteasomes in muscles from tumor-bearing rats. Mol. Biol. Rep. 26, 95-101

Dangin, P., Desport, J. C., Gachon, P. and Beaufrère, B. (1999) Rapid and accurate 13CO2 isotopic measurement in whole bood: comparison with expired gas. Am. J. Physiol. Endocrinol. Metab. 276, E212-E216

Dardevet, D., Sornet, C. and Grizard, J. (1999) Glucocorticoid-induced insulin resistance of protein synthesis is independant of the rapamycin-sensitive pathways in rat skeletal muscle. J. Endocrinol. 162, 77-85

Farges, M. C., Bérard, M.-P., Raul, F., Cézard, J. P., Joly, B., Davot, P., Vasson, M. P. and Cynober, L. (1999) Oral administration of a glutamine-enriched diet before or after endotoxin challenge in aged rats has limited effects. J. Nutr. 129, 1799-1806

Faure, M., Glomot, F., Bledsoe, R., Hutson, S. and Papet, I. (1999) Purification and cloning of the mitochondrial branched-chain amino acid aminotransferase from sheep placenta. Eur. J. Biochem. 259, 104-111

Feillet-Coudray, C., Rock, E., Coudray, C., Grzelkowska, K., Azais-Braesco, V., Dardevet, D. and Mazur, A. (1999) Lipid peroxidation and antioxidant status in experimental diabetes. Clin. Chim. Acta 284, 31-43

Fellmann, N., Ritz, P., Ribeyre, J., Beaufrère, B., Delaitre, M. and Coudert, J. (1999) Intracellular hyperhydration induced by a 7-day endurance race. Eur. J. Appl. Physiol. 80, 353-359

Grzelkowska, K., Dardevet, D., Balage, M. and Grizard, J. (1999) Involvement of rapamycin-sensitive pathway in the insulin regulation of muscle protein synthesis in streptozotocin-diabetic rats. J. Endocrinol. 160, 137-145

Horcajada-Molteni, M. N., Davicco, M. J., Coxam, V., Lebecque, P., Dominguez, B., Ritz, P., Culioli, J. and Barlet, J. P. (1999) Treadmill running tarting three months after orchidectomy restores femoral bone mass in rats. Eur. J. Appl. Physiol. 79, 251-9

Jousse, C., Bruhat, A., Harding, H. P., Ferrara, M., Ron, D. and Fafournoux, P. (1999) Amino acid limitation regulates CHOP expression through a specific pathway independent of the unfolded protein response. FEBS Lett. 448, 211-216

Le, Bricon. J., Farges, M. C., Minet, R., Vasson, M. P. and Cynober, L. (1999) Modulation of immune response with ornithine alpha-ketoglutarate in burn injury: an arginine or glutamine dependency? Nutrition 15, 773-777

Levine, R. L., Berlett, B. S., Moskovitz, J., Mosoni, L. and Stadtman, E. R. (1999) Methionine residues may protect proteins from critical oxidative damage. Mech. Ageing Dev. 107, 323-332

Minet-Quinard, R., Moinard, C., Villié, F., Walrand, S., Vasson, M. P., Chopineau, J. and Cynober, L. (1999) Kinetic impairment of nitrogen and muscle glutamine metabolisms in old glucocorticoid-treated rats. Am. J. Physiol. 276, E558-E564

Moinard, C., Chauveau, B., Walrand, S., Felgines, C., Chassagne, J., Caldefie, F., Cynober, L. and Vasson, M. P. (1999) Phagocyte functions in stressed rats: comparison of modulation by glutamine, arginine and ornithine 2-oxoglutarate. Clin. Sci. 97, 59-65

Morio, B., Gachon, A. M., Boirie, Y., Rousset, P., Gachon, P., Beaufrère, B. and Ritz, P. (1999) Lipolysis, fatness, gender and plasma leptin concentrations in healthy, normal-weight subjects. Eur. J. Nutr. 38, 14-19

Morio, B., Montaurier, C., Ritz, P., Pickering, G., Fellmann, N., Coudert, J., Beaufrère, B. and Vermorel, M. (1999) Time-course effects of endurance training on fat oxidation in sedentary elderly people. Int. J. Obes. Relat. Metab. Disord. 23, 706-714

Mosoni, L., Malmezat, T., Valluy, M. C., Houlier, M. L., Attaix, D. and Patureau Mirand, P. (1999) Lower recovery of muscle protein lost during starvation in old rats despite a stimulation of protein synthesis. Am. J. Physiol. 277, E608-E616
103. Nguyen, L. T., Bedu, M., Caillaud, D., Beaufrère, B., Beaujon, G., Vasson, M. P., Coudert, J. and Ritz, P. (1999) Increased resting energy expenditure is related to plasma TNF- concentration in stable COPED patients. Clin. Nutr. 18, 269-274

Ouédraogo, C. L., Combe, E., Lallès, J. P., Toullec, R., Trèche, S. and Grongnet, J. F. (1999) Nutritional value of the proteins of soybeans roasted at a small-scale unit level in Africa as assessed using growing rats. Reprod. Nutr. Dev. 39, 201-202

Ritz, P., Maillet, A., Blanc, S. and Stubbs, R. J. (1999) Observations in energy and macronutrient intake during prolonged bed-rest in a head-down tilt position. Clin. Nutr. 18, 203-207

Ritz, P., (2000). The physiology of aging, with respect to system changes (circulatory, gastrointestinal, neuroendocrine and immune) and their significance for energy and protein metabolism. Eur. J. Clin. Nutr., 54, S21-S25.

Robinson, L. E., Bussière, F. I., Le, B. J., Farges, M. C., Cynober, L. A., Field, C. J. and Baracos, V. E. (1999) Amino acid nutrition and immune function in tumor-bearing rats: a comparison of glutamine-, arginine- and ornithine 2-oxoglutarate-supplemented diets. Clin. Sci. 97, 657-669

Sebedio, J. L., Vermunt, S. H. F., Chardigny, J. M., Beaufrère, B., Mensink, R. P., Armstrong, R. A., Christie, W. W., Niemela, L., Henon, G. and Riemersma, R.A.. (1999) The effect of dietary trans -linolenic acid on plasma lipids and platelet fatty acid composition : the TransLinE study. Eur. J. Clin. Nutr. 53, 1-10

. Sinaud, S., Balage, M., Bayle, G., Dardevet, D., Vary, T. C., Kimball, S. R., Jefferson, L. S. and Grizard, J. (1999) Diazoxide-induced insulin deficiency greatly reduced muscle protein synthesis in rats: involvement of EIF4E. Am. J. Physiol. 276, E50-E61

Thérond, P., Bonnefont-Rousselot, D., Laureaux, C., Vasson, M. P., Motta, C., Legrand, A. and Delattre, J. (1999) Copper oxidation of in vitro dioleolylphosphatidylcholine enriched HDLs. Physicochemical features and cholesterol effluxing capacity. Arch. Biochem. Biophys. 362, 139-147

Vary, T. C., Dardevet, D., Grizard, J., Voisin, L., Buffière, C., Denis, P., Breuillé, D. and Obled, C. (1999) Pentoxifylline improves insulin action limiting skeletal muscle catabolism after infection. J. Endocrinol. 163, 15-24

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2000
Arnal, M. A., Mosoni, L., Boirie, Y., Gachon, P., Genest, M., Bayle, G., Grizard, J., Arnal, M., Antoine, J. M., Beaufrère, B. and Patureau Mirand, P. (2000) Protein turnover modifications induced by the protein feeding pattern still persist after the end of dietary treatments. Am. J. Physiol. 278, E902-E909

Arnal, M. A., Mosoni, L., Boirie, Y., Houlier, M. L., Morin, L., Verdier, E., Ritz, P., Antoine, J. M., Prugnaud, J., Beaufrère, B. and Patureau Mirand, P. (2000) Protein feeding pattern does not affect protein retention in young women. J. Nutr. 130, 1700-1704

Azais-Braesco, V., Winklhofer-Roob, B., Ribalta, J., Hanley, B., Vasson, M. P., Brtko, J., Brigeluis-Flohe, R. and Bronner, A. (2000) Vitamin A, vitamin E and carotenoid status and metabolism during ageing: functional and nutritional consequences. Endocr. Regul. 34, 97-98

Beaufrère, B. and Morio, B. (2000) Fat and protein redistribution with aging : metabolic considerations. Eur. J. Clin. Nutr. 54, S48-S53

Bérard, M.-P., Zazzo, J.-F., Condat, P., Vasson, M. P. and Cynober, L. (2000) Total parenteral nutrition enriched with arginine and glutamate generates glutamine and limits protein catabolism in surgical hospitalized in intensive care units. Critical Care Medicine 28, 3637-3644

Boirie, Y., Broyer, M., Gagnadoux, M. F., Niaudet, P. and Bresson, J. L. (2000) Alterations of protein metabolism by metabolic acidosis in children with chronic renal failure. Kidney. Int. 58, 236-241

Bonfils, J., Faure, M., Gibrat, J. F., Glomot, F. and Papet, I. (2000) Sheep cytosolic branched-chain amino acid aminotransferase: cDNA cloning, primary structure and molecular modelling and its unique expression in muscles. Biochim. Biophys. Acta 1494, 129-136

Bouteloup-Demange, C., Claeyssens, S., Maillot, C., Lavoinne, A., Lerebours, E. and Dechelotte, P. (2000) Effects of enteral glutamine on gut mucosal protein synthesis in healthy humans receiving glucocorticoids. Am. J. Physiol. Endocrinol. Metab. 278, G677-G681

Bruhat, A., Jousse, C., Carraro, V., Reimold, A., Ferrara, M. and Fafournoux, P. (2000) Amino acids control mammalian gene transcription: activating transcription factor 2 is essential for the amino-acid responsiveness of the CHOP promoter. Mol. Cell. Biol. 20, 7192-7204

Chabanon, H., Persson, L., Wallace, H. M., Ferrara, M. and Brachet, P. (2000) Increased translation efficiency and antizyme-dependentstabilization of ornithine decarboxylase in amino acid-supplementedhuman colon adenocarcinoma cells, Caco-2. Biochem. J. 348, 401-408

Claeyssens, S., Bouteloup-Demange, C., Gachon, P., Hecketsweiler, B., Lerebours, E., Lavoinne, A. and Dechelotte, P. (2000) Effets of enteral glutamine on leucine, phenylalanine and glutamine metabolism in hypercortisolemic subjects. Am. J. Physiol. Endocrinol. Metab. 278, E817-E824

Dardevet, D., Sornet, C., Balage, M. and Grizard, J. (2000) Stimulation of in vitro rat muscle protein synthesis by leucine decreases with age. J. Nutr. 130, 2630-2635

Desport, J. C., Preux, P. M., Guivarc'h, S., Rousset, P., Salle, J. Y., Daviet, J. C., Dudognon, P., Munoz, M. and Ritz, P. (2000) Total body water and percentage fat mass measurements using bioelectric impedance analysis and anthropometry in spinal cord-injured patients. Clin. Nutr. 19, 185-190

Gorbea, C., Taillandier, D. and Rechsteiner, M. (2000) Mapping subunit contacts in the regulatory complex of the 26S proteasome S2 and S5b form a tetramer with ATPase subunits S4 and S5. J. Biol. Chem. 275, 875-882

Grolier, P., Boirie, Y., Levadoux, E., Brandolini, M., Borel, P., Azais-Braesco, V., Beaufrère, B. and Ritz, P. (2000) Age-related changes in plasma lycopene concentrations, but not in vitamin E, are asociated with fat mass. Br. J. Nutr. 84, 711-716.

Hayes, H., Bonfils, J., Faure, M. and Papet, I. (2000) Assignment of BCAT1, the gene encoding cytosolic branched chain aminotransferase, to sheep chromosome band 3q33 and to cattle and goat chromosome bands by in situ hybridization. Cytogen. Cell Gen. 90, 84-85

Henry, C. J. K., Ritz, P., Roth, G. S., Lane, M. and Dolomons, N. W. (2000) Report of the IDECG Working Group on the ibology of aging. Eur. J. Clin. Nutr. 54, suppl 3, S1-S3

Jousse, C., Bruhat, A., Ferrara, M. and Fafournoux, P. (2000) Evidence for multiple signaling pathways in the regulation of gene expression by amino acids in human cell lines. J. Nutr. 130, 1555-1560

Lin, H., Keriel, A., Morales, C. R., Bedard, N., Zhao, Q., Hingamp, P., Lefrançois, S., Combaret, L. and Wing, S. S. (2000) Divergent N-terminal sequences target an inducible testis deubiquinating enzyme to distinct subcellular structures. Mol. Cell. Biol. 20, 6568-6578

Loreau, O., Maret, A., Poullain, D., Chardigny, J. M., Sebedio, J. L., Beaufrère, B. and Noël, J. P. (2000) Large-scale preparation of (9Z,12E)-[1-13C]-octadeca-9,12-dienoic acid, (9Z,12Z,15E)-[1-13-C]-octadeca-9,12,15-trienoic acid and their [1-13C] all-cis isomers. Chem. Phys. Lipids 106, 65-78

Malmezat, T., Breuillé, D., Capitan, P., Patureau Mirand P. and Obled, C. (2000) Glutathione turnover is increased during the acute phase of sepsis in rats. J. Nutr. 130, 1239-1246

Malmezat, T., Breuillé, D., Pouyet, C., Buffière, C., Denis, P., Patureau Mirand P. and Obled, C. (2000) Methionine transsulfuration is increased during sepsis in rats. Am. J. Physiol. 279, E1391-E1397

Mezzarobba, V., Bielicki, G., Jeffrey, F. M. H., Mignon, M., Renou, J. P., Grizard, J. and Meynial-Denis, D. (2000) Lack of effect of aging on acetate oxidation in rat skeletal muscle during starvation A 13C NMR study. J. Exp. Biol. 203, 995-1001

Minet-Quinard, R., Moinard, C., Walrand, S., Villié, F., Normand, B., Vasson, M. P., Chopineau, J. and Cynober, L. (2000) Induction of a catabolic state in rats by dexamethasone: dose or time dependency? J. Parenter. Enter. Nutr. 24, 30-36

Moinard, C., Caldefie, F., Felgines, C., Vasson, M. P. and Cynober, L. (2000) Involvement of glutamine, arginine and polyamines in the ornithine alpha-ketoglutarate actions on macrophage functions from stressed rats. J. Leukoc. Biol. 67, 834-840

Mordier, S., Deval, C., Béchet, D., Tassa, A. and Ferrara, M. (2000) Leucine Limitation Induces Autophagy and Activation of Lysosome-dependent Proteolysis in C2C12 Myotubes through a Mammalian Target of Rapamycin-independent Signaling Pathway. J. Biol. Chem. 275, 29900-29906

Morio, B., Barra, V., Ritz, P., Fellmann, N., Bonny, J. M., Beaufrère, B., Boirie, Y. and Vermorel, M. (2000) Benefit of endurance training in elderly people over a short period is reversible. Eur. J. Appl. Physiol. 81, 329-336

Ritz, P., (2000). The physiology of aging, with respect to system changes (circulatory, gastrointestinal, neuroendocrine and immune) and their significance for energy and protein metabolism. Eur. J. Clin. Nutr., 54, S21-S25.

Ritz, P. (2000). Body water spaces and cellular hydration during healthy aging. Ann. N. Y. Acad. Sci. 904, 474-483

Rochon, C., Tauveron, I., Dejax, C., Benoit, P., Capitan, P., Bayle, G., Prugnaud, J., Fabricio, A., Berry, C., Champredon, C., Thiéblot, P. and Grizard, J. (2000) Response of leucine metabolism to hyperinsulinemia in hypothyroid patients before and after thyroxine replacement. J. Clin. Endocrinol. Metab. 85, 697-706

Ruot, B., Breuillé, D., Rambourdin, F., Bayle, G., Capitan, P. and Obled, C. (2000) Synthesis rate of plasma albumin is a good indicator of liver albumin synthesis in sepsis. Am. J. Physiol. 279, E244-E251

Samuels, S. E. and Attaix, D. (2000) Fasting does not increase mRNA levels of proteolytic systems in small intestinal mucosa of the rat. J. Nutr. Biochem. 11, 496-499

Samuels, S. E., Knowles, A. L., Tilignac, T., Debiton, E., Madelmont, J. C. and Attaix, D. (2000) Protein metabolism in the small intestine during cancer cachexia and chemotherapy in mice. Cancer Res. 60, 4968-4974

Sebedio, J. L., Vermunt, S. H. F., Chardigny, J. M., Beaufrère, B., Mensink, R. P., Armstrong, R. A., Christie, W. W., Niemela, L., Henon, G. and Riemersmar, A. (2000) The effect of dietary trans -linolenic acid on plasma lipids and platelet fatty acid composition : the TransLinE study. Eur. J. Clin. Nutr. 54, 104-113

Tesseraud, S., Chagneau, A. M. and Grizard, J. (2000) Muscle protein turnover during early development in chickens divergently selected for growth rate. Poult. Sci. 79, 1465-1471

Walrand, S., Chambon-Savanovitch, C., Felgines, C., Chassagne, J., Raul, F., Normand, B., Farges, M. C., Beaufrère, B., Vasson, M. P. and Cynober, L. (2000) Aging : a barrier to renutrition ? Nutritional and immunological evidence in rat. Am. J Clin. Nutr. 72, 816-824

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2001
Attaix, D., Combaret, L., Pouch, M.N. et Taillandier, D. Regulation of proteolysis. Current Opinion in Clinical Nutrition and Metabolic Care, 2001, 4, 45-49.

Balage, M., Sinaud, S., Prod'Homme, M., Dardevet, D., Vary, T.C., Kimball, S.R., Jefferson, L.S. et Grizard, J. Amino acids and insulin are both required for regulating assembly of the elf4E-elF4G complex in rat skeletal muscle. American Journal of Physiology - Endocrinology and Metabolism, 2001, 281, E565-E574.

Bernhard J., Beaufrere B., Laville M., Fouque D., 2001. Adaptive response to a low protein diet in predialysis chronic renal failure patients. J. Am. Soc. Nephr., 12, 1249-1254.

Boirie Y., 2001. Régulation de la masse musculaire. Ann. Kinésithér., 28, 205-207.

Boirie Y., Beaufrere B., Ritz P., 2001. Energetic cost of protein turnover in healthy elderly humans. Int. J. Obesity, 25, 601.605.

Boirie Y., Gachon P., Cordat N., Ritz P., Beaufrere B., 2001. Differential insulin sensitivity of glucose, amino acids and albumin metabolism in elderly men and women. J. Clin. Endocrinol. Metab., 86 : 638.644.

Boirie Y., Short K.R., Ahlman B., Charlton M., Nair S., 2001. Tissue-specific regulation of mitochondrial and cytoplasmic protein synthesis rates by insulin. Diabetes, 50, 2652-2658.

Bretillon L., Chardigny J.M., Sebedio J.L., Noel J.P., Scrimgeour C.M., Fernie C.E., Loreau O., Gachon P., Beaufrere B., 2001. Isomerization increases the postprandial oxidation of linoleic acid but not a-linolenic acid in men. J. Lip. Res., 42, 995-997.

Bruhat, A. et Fafournoux, P. Recent advances on molecular mechanisms involved in amino acid control of gene expression. Current Opinion in Clinical Nutrition and Metabolic Care, 2001, 4, 439-443.

Caldefie-Chézet F., Moinard C., Minet-Quinard R., Gachon F., Cynober L.,Vasson M-P. Dexamethasone treatment induces long-lasting hyperleptinemia and anorexia in old rats. Metabolism 2001; 50:1054-1058.

Caldefie-Chézet F., Poulin A., Tridon A., Sion B., Vasson M-P. Leptin : a potential regulator of polymorphonuclear neutrophil bactericidal action? J. Leukoc. Biol. 2001; 69:414-418.

Chambon-Savanovitch C., Felgines C., Walrand S., Raul F., Zarrabian S., Meunier M-T., Farges M-C., Cynober L., M-P. Vasson. A pancreatic extract-enriched diet improves the nutritional status of aged rats. J.Nutr. 2001; 131:813-819.

Combaret, L., Taillandier, D. et Attaix, D. Nutritional and hormonal control of protein breakdown. American Journal of Kidney Diseases, 2001, 37 (suppl. 2), S108-S111.

Dangin M., Boirie Y., Garcia-Rodenas C., Gachon P., Fauquant J., Callier P., Ballevre O., Beaufrere B., 2001. The digestion rate of protein is an independent regulating factor of postprandial protein retention. Am. J. Physiol. Endocrinol. Metab., 280 : E340-E348.

Desport J.C., Preux P.M., Magy L., Boirie Y., Vallat J.M., Beaufrere B., Couratier P., 2001. Factors correlated with hypermetabolism in patients with amyotrophic lateral sclerosis. Am. J. Clin. Nutr., 74, 328-334.

Deval, C., Mordier, S., Obled, C., Béchet, D., Combaret, L., Attaix, D. et Ferrara, M. Identification of cathepsin L as a differientally expressed message associated with muscle wasting. Biochemical Journal, 2001, 360, 143-150.

Faure, M., Glomot, F. et Papet, I. Branched-chain amino acid aminotransferase activity decreases during development in skeletal muscles of sheep . Journal of Nutrition, 2001, 131, 1528-1534.

Gellis C., Sautou-Mirand V., Arvouet A., Vasson M-P., Chopineau J. Stability of methylprednisolone sodium succinate in pediatric parenteral nutrition mixtures. Am. J. Health Syst. Pharm. 2001;58:1139-1142.

Grizard, J., Dardevet, D., Savary, I., Mosoni, L., Meynial-Denis, D., Arnal, M.A. et Patureau Mirand, P. Implication de l'insuline et des glucocorticoïdes dans la fonte protéique musculaire chez le rat au cours du vieillissement. Age et Nutrition, 2001, 12, 182-188.

Humbert, B., Nguyen, P., Obled, C., Bobin, C., Vaslin, A., Sweeten, S. et Darnaum, D. Use of L-[15N] glutamic acid and homoglutathione to determine both glutathione synthesis and concentration by GCMS. Journal of Mass Spectrometry, 2001, 36, 726-735.

Jousse, C., Bruhat, A., Carraro, V., Urano, F., Ferrara, M., Ron, D. et Fafournoux, P. Inhibition of CHOP (C/EBF homologous protein) translation by a peptide encoded by upstream open reading frames. Nucleic Acids Research, 2001, 29, 4341-4351.

Lafarge, S., Sylvain, V., Ferrara, M. et Bignon, Y.J. Inhibition of BRCA1 leads to increased chemoresistance to microtubule-interfering agents, an effect that involves the JNK pathway. Oncogene, 2001, 20, 6597-606.

Larbaud, D., Balage, M., Taillandier, D., Combaret, L., Grizard, J. et Attaix, D. Differential regulation of the lysosomal, Ca2+-dependent and ubiquitin/proteasome-dependent proteolytic pathways in fast-twitch and slow-twitch rat muscle following hyperinsulinemia. Clinical Science, 2001, 101, 551-558.

Le Bacquer, O., Nazih, H., Blottiere, H., Meynial-Denis, D., Laboisse, C. et Darmaun, D. Linkout effects of glutamine deprivation on protein synthesis in a model of human enterocytes in culture. American Journal of Physiology - Gastrointestinal and Liver Physiology, 2001, 286, G1340-G1347.

Levadoux E, Morio B, Montaurier C, Puissant V, Boirie Y, Fellmann N, Brandolini M, Picard B, Rousset P, Beaufrere B, Ritz P., 2001. Reduced whole body fat oxidation in women and in the elderly. Int. J. Obesity, 25, 39-44.

Morio B., Hocquette J.F., Montaurier C., Boirie Y., Bouteloup-Demange C., McCormack C., Fellmann N., Beaufrere B., Ritz P., 2001. Muscle fatty acid oxidative capacity is a determinant of whole body fat oxidation in elderly people. Am. J. Physiol. 280: E143-E149.

Ritz P. and investigators of the Source Study and of the Human Nutrition Research Centre-Auvergne, 2001. Chronic cellular dehydration in the aged patient. J. Gerontol., 56A, N° 6, M349-M352.

Rousset S., Brandolini M., Martin J.F., Droit-Volet S., Bonin D., Lhoutellier P., Simon H., Vergote M.H., Boirie Y., 2001. La part de la viande dans les apports protéiques de sujets âgés vivant à domicile. Cah. Nutr. Diét., 36, 417-425.

Samuels, S.E., Knowles, A.L., Tilignac, T., Debiton, E., Madelmont, J.C. et Attaix, D. Higher skeletal muscle protein synthesis and lower breakdown after chemotherapy in cachectic mice. American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 2001, 281, R133-R139.

Savary, I., Debras, E., Dardevet, D., Rambourdin, F., Obled, C. et Grizard, J. Evidence for an alteration of acute phase protein response to dexamethasone in aging rats. Mechanisms of Ageing and Development, 2001, 122, 105-120.

Souweine, B., Combaret, L., Taillandier, D. et Attaix, D. La protéolyse ubiquitine-protéasome dépendante : une machinerie complexe dans la destruction sélective et hautement régulée des protéines. Nutrition Clinique et Métabolisme, 2001, 15, 23-31.

Tournu, C., Obled, A., Ferrara, M., Omura, S. et Bechet, D. Glucose regulates protein catabolism in ras-transformed fibroblasts through a lysosomal-dependent proteolytic pathway. Biochemical Journal, 2001, 357, 255-261.

Vermunt S.H.F., Beaufrere B., Riemersma R.A., Sebedio J.L., Chardigny J.M., Mensink R.P., and the TransLinE investigators, 2001. Dietary trans –linolenic acid from deodorised rapeseed oil and plasma lipids and lipoproteins in healthy men : the TransLinE study. Brit. J. Nutr., 85, 387-392.

Walrand S., Moreau K, Caldefie F., Tridon A., Chassagne J., Portefaix G., Cynober L., Beaufrere B., Vasson MP., Boirie Y., 2001. Specific and nonspecific immune responses to fasting and refeeding differ in helathy young adult and elderly persons. Am. J. Clin. Nutr., 74, 670-678.

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2002
Alliot, J., Jourdan, D., Boghossian, S., Veyrat-Durebex, C., Pickering, G., Meynial-Denis, D. et Gaumet, N. The LOU/c/jall rat as an animal model of healthy aging. Journal of Gerontology, 2002, 57, B312-B320.

Arnal, M.A., Mosoni, L., Dardevet, D., Ribeyre, M.C., Bayle, G., Prugnaud, J. et Patureau Mirand, P. Pulse protein feeding pattern restores stimulation of muscle protein synthesis during the feeding period in old rats. Journal of Nutrition, 2002, 132, 1002-1008.

Attaix, D., Combaret, L., Pouch, M.N. et Taillandier, D. Cellular control of ubiquitin-proteasome-dependent proteolysis. Journal of Animal Science, 2002, 80, (E Suppl. 2), E56-E63.

Baquet, G, Berthoin S, Dupont G, Blondel N, Fabre C, Van Praagh E. Effect of high intensity intermittent training on peak vdot;O2 in prépubertal children. Int J Sports Med, 2002, 23, 439-44.

Beaufrere B. “Métabolisme des acides aminés chez l’homme normal” Flammarion Médecine-Sciences – Journées de Diabétologie 2002, 94 :103.

Beaufrere B. « Les Allégations Santé : de l’aliment au médicament ? » Cah. Nutr. Diét., 37, 3, 200.

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