Pulmonary bacteria to protect against certain respiratory diseases

Pulmonary bacteria with immune-modulating properties that protect against asthma have been isolated from healthy baby mice.

Pulmonary bacteria to protect against certain respiratory diseases
Updated on 10/06/2017
Published on 08/28/2017

Asthma is a chronic, incurable, multi-factorial pathology whose incidence is increasing in industrialised countries. No long-lasting curative treatment is currently available for this chronic pathology.

A bacterium with immune-modulating properties from the Enterococcus species has been isolated in the healthy lungs of baby mice. It protects them from growth delay due to asthma that diminishes the Th2 signature present in allergic asthma.

Other pulmonary strains have been isolated and tested for their ability to protect baby mice against asthma. This panel of strains offers good candidates for probiotics.

Contact(s)
Technology Transfer Officer:
Héloïse Simonson (+33 (0)6 47 05 15 98)

Patents

Bacterial strains as agents to prevent and/or treat respiratory diseases

N° and date of publication    FR3047010 - 2017-07-28 (BOPI 2017-30)

N° and date of filing    FR1650656 - 2016-01-27

Applications: Prevention of allergic asthma and other respiratory diseases

Publication

  • Remot A., Descamps D., Noordine M-L, Boukadiri A., Mathieu E., Robert V., Riffault S., Lambrecht B., Langella P., Hammad H., Thomas M., Bacteria isolated from lung modulate asthma susceptibility in mice. The ISME Journal (2017) 11, 1061-1074