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Strain producing erythritol and/or erythrulose

New strains of Yarrowia lipolytica which can produce improved yields of erythritol and erythrulose.

Souche productrice d'erythritol et/ou d'erythrulose
Updated on 04/10/2018
Published on 01/23/2018

Two genes involving erythritol catabolism have been identified in the yeast Y. lipolytica. The two strains obtained are efficient in the production of erythritol and erythrulose. These strains result from a partnership between INRA (BIMlip team, INRA-AgroParisTech Joint Research Unit for Food and Gut Microbiology for Human Health; UMR MICALIS) and the University of Liege (Gembloux Agro-bio Tech).


The process is based on the biological synthesis of two compounds rather than using chemical synthesis. The productivity and yield of erythritol and erythrulose are increased. The gene was unknown until now in the yeast; once produced, erythritol is not reconsumed by the strain. Several health claims have been accepted by the European Commission (beverages, sweetening agent).


Erythritol is used in pharmaceuticals, cosmetics and the agrifood industry as a sweetener, additive and food protection agent, a flavouring agent and antioxidant agent. Erythrulose is a synthon for chemical synthesis (medicinal products) and cosmetics (self-tanning agent).

INRA Transfert Valorisation Manager:
Laure AKOMIA, (01 42 75 94 43)


  • PCT/EP2017/060823

Type of transfer proposed

License on a patent or licensing option with an R&D programme for validation (TRL 3).