tRNA & aminoacyl-tRNA synthetase table | taaRSAt home page


tRNALeu (cytosolic and mitochondrial [imported])

(aminoacylated by LeuRS)

Codons and anticodons
codons read by: codon usage (codons/1000)
cytosol mitochondria
CUA anticodons IAG, UAG 10.0 14.7
CUC anticodon IAG 15.9 17.8
CUG anticodon CAG 9.9 11.9
CUU anticodon IAG 24.3 25.1
UUA anticodon UAA 12.9 21.9
UUG anticodon CAA 21.0 21.4

Codon usage statistics are from the Codon Usage Database at the Kazusa DNA Research Institute.

In the sequences below, several regions of interest have been marked, including the low stability regions (TATA-like sequences) in the 5'-flanks thought to be important for high transcriptional activity, the CAA triplets thought to indicate the region of transcription initiation and the poly(T) stretches thought to act as transcription terminators. Bases which vary between isoacceptors are highlighted, as are anticodons.


Anticodon AAG, probably modified to IAG

5' flanks
Leu(AAG)_1
CGTAGGAATAATTTGAATAAATAATTATGTTTTCTTTCTAGAACACAAAA
Leu(AAG)_2
TTAGGTCAAAATATATTATAGATAAAACAACGTTGCAAGGAGTACAAAAT
Leu(AAG)_3
GAGAGTAGTTTTATATTCAAATTACATGCATGCAACTAAGTAGCAACAAA
Leu(AAG)_4
GTCCGGGAACTTTGGTTTAGTAATTTAGAAATCGAAACAGAGCAACAAAA
Leu(AAG)_5
AAGTTAATGGTTTAACCCAAAATATTTAAAAGTGTCAGTAGAACATAGAC
Leu(AAG)_6
TTTCTCTATTACTGACCTATATTGATTAAAATATGTTGATAGAACAACAA
Leu(AAG)_7
GGAGAATTATTCTAAAGATAAAACCGTTTAGTGGATTTGGTTACCAAAAT
Leu(AAG)_8
ATATTTGAAACTGTAGTCTATATATTTAGATTTAATATTTTATACAACAA
Leu(AAG)_9
ACGATGAGATGTAAAATTTGAAGCTTGAAGATGAACGTTGTTAACAAAAA
             A
           G-C
           T-A
           T-A
           G-C
           A-T
           T*G
           A-T     TA
 TTGA     T   CACCC  A
G    GCCGG    |||||  A
G     |||     GTGGG  C
 T   AGGC     C    TT
  CTA    G   T G
          C-G C-G
          C-G  C-G
          A-T   G A
          G-C    AA
          A-T     
         T   T     
         T   G      
          AAG        

3' flanks
Leu(AAG)_1
TTTCCTTTTTTTTTTTGTTTTTTTC
Leu(AAG)_2
TTACTCTTTTTTAGTTTTTGACTAC
Leu(AAG)_3
TTCTCTTTTTCTCAAATTAATATTT
Leu(AAG)_4
ATTTACTTTTTTGTCTTTTGGTGGA
Leu(AAG)_5
AATCCTAATTTTTTGGAGATTGTTT
Leu(AAG)_6
TTACAGTTTTTTTGTTTTGTTTTGT
Leu(AAG)_7
TAATTATTATTATTATTTTTTTTTT
Leu(AAG)_8
TTCACTTTTTTCTCTTTTTCCATTA
Leu(AAG)_9
TTCTCTCTTTTTTTTTTTTTAAACG

Observations:

none

Variants:

Leu(AAG)_9
T20b->C


Anticodon CAA

5' flanks
Leu(CAA)_1
GTCATATTTGTAAGGGAATATAAATTAAAAACTCATAATAATATCAACGA
Leu(CAA)_2
TATAAGTAGTTTAAAATAGATATTTCATTGTGAAAATATGATTGTAAAGA
Leu(CAA)_3
ATCCGTTTAATCTATGTCAATTAAGTTTAGTGTAGTTATACAAACAAAAA
Leu(CAA)_4
TTGAAAATTATACGATTATTTACACTATATACGTATAAGTTTAACAAAAA
Leu(CAA)_6
ACTAGGTGTTAATCACTATATATAGTTTGTAGTAGAAAACAATATCAAAA
Leu(CAA)_7
TAGTTTTTTCATCCTGCTATATATGTTGTCAATGATATTTAATAAAGAAG
Leu(CAA)_8
CAGCTAACAATTTGCAACTAAAACTACACAGAGTAGAGTATTAAGCAGAA
Leu(CAA)_9
TATCGTTTTTTCTCGATTATATATTTGTAGTATGTCTTGATATCAAACAA
             A
           G-C
           T-A
           C-G
           A-T
           G-C
           G*T
           G*T     TA
  TGA     T   CACCC  A
 G   GCCGG    |||||  A
 G    |||     GTGGG  C
 T   AGGC     C    TT
  CTA    G   T G
          C-G C-G
          C-G  C-G
          A-T   T-A
          G-C    C-G
          A-T     G A
         C   T     TA
         T   G      
          CAA        

3' flanks
Leu(CAA)_1
TTCATTTTTATTTTTCTTACCCATT
Leu(CAA)_2
TTTAATTTTATTAAATTTTTAGCAT
Leu(CAA)_3
TTTTTATTTTGTTATTTTTCCCTTT
Leu(CAA)_4
TTTATTTTTGTGCATTTCTTTTTGT
Leu(CAA)_6
TTTCTGTTTTTAGTTTTATGTTCAA
Leu(CAA)_7
TTAGTTTTTTGTTACAGTTTCTGCG
Leu(CAA)_8
TTTTTATTATTTTCTTTTTAAGTTT
Leu(CAA)_9
ATTTAGATTTTTATTTTCTCTGAGC

Observations:

none

Variants:

Leu(CAA)_1
G7->T  Ce12->T  Te2->A  Ae3->G  T66->A
Leu(CAA)_4
G7->A  Ce12->T  Te2->A
Leu(CAA)_6 Leu(CAA)_9
G7->A  T60->C
Leu(CAA)_7
G7->A  Ce12->T  T60->C

Putative pseudogenes:

Leu(CAA)_10 Leu(CAA)_11 Leu(CAA)_5

Anticodon CAG

5' flanks
Leu(CAG)_2
TATCATATAAATATATGATATATAATTGGTATTGTTTAAGTCAACATAAA
Leu(CAG)_3
TATTTGTAATATGTTTTGATATAAATATGTCTGATTTCAGTTATTAAAAA
             A
           G-C
           T-A
           C-G
           A-T
           A-T
           G-C
           A-T     TA
 TTGA     T   CACCC  A
G    GCCGG    |||||  A
G     |||     GTGGG  C
 T   AGGC     C    TT
  CTA    G   T G
          C-G C-G
          C-G  C-G
          A-T   G A
          G-C    AA
          T-A     
         T   T     
         T   G      
          CAG        

3' flanks
Leu(CAG)_2
TTTCTTTTTATGCTTTCAAAAAAAA
Leu(CAG)_3
TATTCTTTTTGTATTTAACTATTTA

Observations:

none


Anticodon GAG

5' flanks
Leu(GAG)_1
GTCAATGGTTACTTGATAAATATAGAAACTTTGAAGATTGTATAACAAGA
             A
           G-C
           T-A
           G-C
           G A
           C-G
           T-A
           G-C     TT
  TGA     T   GACCC  A
 G   CATAA    |||||  G
 G   ||||     CTGGG  C
  T  GTAT     C    CT
   TA    T   G A
          C-G G
          T-A  
          A A   
          C-G    
          G-C     
         T   C     
         T   G      
          GAG        

3' flanks
Leu(GAG)_1
CTATCTTTCATCATAATGTCTTCCA

Observations:

unusual T loop sequence: GCTC instead of GTTC

This tRNA is clearly derived from a tRNAHis gene with a mutated anticodon. The lack of a poly(T) terminator may prevent expression of this probable pseudogene.


Anticodon UAA

5' flanks
Leu(TAA)_1 Leu(TAA)_5
GGGTTGTAGAATAATAACAAGTACTTGGTTTATTAACAGATATTCAATAA
Leu(TAA)_2
TTGTATATTTACTGGTTATATATATGTAATAAGTATGAATATTAACAAAT
Leu(TAA)_3
TTCCTGTTTGAGAATTGTGATTGTTCTCTCAGTAGTCAATAGACAAGAAG
Leu(TAA)_4
TACACCAGTTTGCGTATATAAATATAATAGGAAGAGAAAAATAATAACAA
Leu(TAA)_6
AGATACAAACGTTTATTAAGAAGGTTATATTTCATATGAGTGACATCAAG
Leu(TAA)_7
AGAAATACGATTACTAAATAAACTTAAAAATGGAATATTTAAACAGCAGC
             A
           G-C
           C-G
           A-T
           G-C
           G-C
           T*G
           T-A     CA
  TGA     T   CACCC  A
 G   GCCCG    |||||  G
 G    |||     GTGGG  C
  T  AGGG     C    TT
   TA    G   T G
          G-C G-C
          A-T  C-G
          A-T   A-T
          G-C    C-G
          A-T     A A
         C   T     TA
         T   G      
          TAA        

3' flanks
Leu(TAA)_1 Leu(TAA)_5
TCTTTCTCTTTATTTTTTGAAATTT
Leu(TAA)_2
ATTTATATTTTTGTTAATTTTAAAT
Leu(TAA)_3
TATTTTTCCTAAAATCTTTTTTCCT
Leu(TAA)_4
TTTCCCCTCTATTTTGTTAAAATTA
Leu(TAA)_6
TTTGTATTTTTTTTTCATTTTTCTG
Leu(TAA)_7
GTTTTGCTTTTGTTTTATATAATTT

Observations:

none

Variants:

Leu(TAA)_2
insertion(s)
Leu(TAA)_6 Leu(TAA)_7
T16->A


Anticodon UAG

5' flanks
Leu(TAG)_1
ATAATTAAAACATTAGTATAAATACAATCACATGCTTAATGTAATAATGT
Leu(TAG)_2
TTAAAATGTGGATTGCTTTATATAAATAGTTTATGATGCTCTTAACAATT
Leu(TAG)_3
GGATCTTTCAAGTATAATATATAAAATCTAATCTCAATACAAACACAAAG
Leu(TAG)_5
AACTAAAGTATTATGCTATAAATAATCGTGTTGCGGAGCTATCAACAAAT
Leu(TAG)_6
AATTTTATTGTTAATTATAGAATGTTTAAGTTTCACATATCATACAACAA
Leu(TAG)_7
AATCTGAATTGTAAGTACTAAATTAAACTTAAAGAGTCATATAAACATCT
             A
           G-C
           A-T
           C-G
           A-T
           G-C
           T*G
           T-A     TA
  TGA     T   CACCC  A
 G   GCCGG    |||||  A
 G    |||     GTGGG  C
 T   AGGC     C    TT
  CTA    G   T G
          C-G C-G
          C-G  C-G
          A-T   G A
          G-C    AA
          A-T     
         T   C     
         T   G      
          TAG        

3' flanks
Leu(TAG)_1
ATTTGTTTTTTTCTTTGACTCCTTT
Leu(TAG)_2
AATAAATTTTGAACAATTGTACTGC
Leu(TAG)_3
TTTAGATTTATTTTTTCCAGACTTT
Leu(TAG)_5
AATATTTTTTTTATATTCTTTTGTC
Leu(TAG)_6
ATTTCTTTTCCTTTTTTTCCCTTCT
Leu(TAG)_7
ATTCCTTTTTTTTCTTTTGTTCCTT

Observations:

none

Variants:

Leu(TAG)_2 Leu(TAG)_3 Leu(TAG)_5
G5->A  C68->T


tRNA & aminoacyl-tRNA synthetase table | taaRSAt home page

Last updated December 12, 1999; Ian Small