20 Jan 2017
31 Jan 2017
06 Jan 2017
The first ever cloned calves, in INRA’s Developmental Biology and Reproduction research unit in Jouy en Josas. © INRA, PAILLARD Gérard

Low birth rate after cloning: the consequences of highly disruptive interactions between uterus and embryo

When comparing cloned animal embryos and embryos that come about as a result of artificial insemination, there is a difference in gene expression at the moment implantation occurs in the uterus for more than 5 000 genes. Researchers at INRA and the University of California are shining the spotlight on this critical step for the survival of cloned embryos in cattle. Published in the 8 December 2016 issue of the journal Proceedings of the National Academy of Sciences, these findings are furthering knowledge of hitherto poorly-understood mechanisms that govern interactions between cloned embryos and the uterus. They may hold the key to improving cloning in mammals.

Metaprogrammes
  • Biofilm mixte de Lactococcus lactis (coques jaunes) et de Listeria monocytogenes (bâtonnets roses), observé en microscopie électronique à balayage.. © inra, Thierry MEYLHEUC
  • Supermarché. © MAITRE Christophe
  • Ciel d'orage en Eure et Loir.. © INRA, WEBER Jean
  • Floating market.. © INRA, Chloé Le Bastard
  • Céréales et tournesols fleuris sur fond de ciel.. © INRA, BEGUEY Alain