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Neurobiology of Depression: Road to Novel Therapeutics. © Academic Press, Academic Press

Neurobiology of Depression - Road to Novel Therapeutics

Understanding major depressive disorder by combining the basic concepts of neurobiology underlying the disease and the most recent advances in research.

By Catherine Foucaud-Scheunemann
Updated on 02/21/2019
Published on 02/19/2019

Depression is one of the most common mental-health disorders caused by a variety of genetic, biological, environmental and psychological factors.  Major depressive disorder (MDD) is typically treated with first-line antidepressant agents that primarily target monoamine neurotransmission. However, only approximately one-third of patients with MDD achieve remission following a trial with such an antidepressant. 

Neurobiology of Depression: Road to Novel Therapeutics synthesizes the basic neurobiology of major depressive disorder with discussions on the most recent advances in research, including the interacting pathways implicated in the pathophysiology of MDD, omics technologies, genetic approaches, and the development of novel optogenetic approaches that are changing research perspectives and revolutionizing research into depression. These basic foundational understandings on the neurobiology underlying the disorder, along with a comprehensive summary of the most recent advances in research are combined in this book to aid advanced students and researchers in their understanding of MDD.


Neurobiology of Depression: Road to Novel Therapeutics.  Joao Quevedo Andre Carvalho Carlos Zárate (Eds). Academic Press (Waltham, US). 471 pages. Date of publication: 8 January 2019.
eBook ISBN: 9780128133347. Paperback ISBN: 9780128133330. More information

With the contribution of Lison Huet, Ines Delgado, Bruno Aouizerate, Nathalie Castanon, and Lucile Capuron, Joint Research Unit for Nutrition and Integrated Neurobiology (INRA, Univ. Bordeaux) as authors of the chapter - Obesity and Depression: Shared Pathophysiology and Translational Implications.